Recent advances in reaction-based fluorescent probes for detecting monoamine oxidases in living systems

文献情報

出版日 2019-04-24

DOI 10.1039/C9AN00409B

インパクトファクター 4.616

著者

Jintao Huang, Danqi Hong, Wenjie Lang, Jian Liu, Jia Dong, Chaonan Yuan, Jie Luo, Jingyan Ge, Qing Zhu

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要旨

Monoamine oxidase (MAO) is a membrane-bound mitochondrial enzyme that plays an important role by catalyzing oxidative deamination to maintain the homeostasis of neurotransmitters and other biogenic amines in living systems. MAO activity is critical for the brain and central nervous system. Its dysfunction is closely related with many neurological and psychiatric disorders. Fluorescent probes provide a useful approach to accurately detect MAO activity and assist to better elucidate their biological functions. Herein, in this Minireview, we summarize the recent advances in reaction based MAO type fluorescent probes and their imaging applications in living systems.

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Analyst

CiteScore: 7.8

自己引用率: 5.6%

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Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Recent advances in reaction-based fluorescent probes for detecting monoamine oxidases in living systems

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