The coupling of in-flow reaction with continuous flow seedless tubular crystallization

文献情報

出版日 2019-01-18

DOI 10.1039/C8RE00313K

インパクトファクター 4.239

著者

Bart Rimez, Jean Septavaux, Benoit Scheid

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要旨

The direct coupling between a continuous flow-assisted acetylation reaction of salicylic acid and the subsequent crystallisation of aspirin in a continuous flow tubular reactor or nucleator is investigated. The design of the reactor relies on a 3 minute residence time, followed by quenching with water prior to cooling inside the tubular nucleator. By appropriate selection of the temperature of the nucleation step, the number of nuclei formed in the tubular setup is accurately controlled. In this way, pure crystalline aspirin is continuously obtained with a desired mean crystal size between 3 μm and 300 μm and a reduced dispersion grade, avoiding seeding and micronisation steps.

掲載誌

Reaction Chemistry & Engineering

CiteScore: 0

自己引用率: 8.8%

年間論文数: 284

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.

The coupling of in-flow reaction with continuous flow seedless tubular crystallization

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