A diversity of alkylation/acylation products of uracil and its derivatives: synthesis and a structural study

文献情報

出版日 2018-12-10

DOI 10.1039/C8OB02552E

インパクトファクター 3.876

著者

Olga Michalak, Piotr Cmoch, Piotr Krzeczyński, Marcin Cybulski

原文を見る

要旨

tert-Butyl dicarbonate (Boc2O) and ethyl iodide (EtI) reactions with uracil (U), thymine (T) and 6-methyluracil (6-MU) were performed following routine procedures in pyridine/DMF solvents and with DMAP as the catalyst. Among 20 synthesized compounds, a derivative of 6-methyluracil substituted by the Boc-pyridine moiety at the C5 position appeared unexpectedly. The NMR spectra confirmed the molecular structure of all uracil derivatives. Parallel quantum mechanical DFT calculations supported the experimental findings.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

A diversity of alkylation/acylation products of uracil and its derivatives: synthesis and a structural study

文献情報

おすすめジャーナル

関連文献

Theoretical study on geometric, electronic and catalytic performances of Fe dopant pairs in graphene

The influence of polyanion molecular weight on polyelectrolyte multilayers at surfaces: elasticity and susceptibility to saloplasticity of strongly dissociated synthetic polymers at fluid–fluid interfaces

Strain-induced ferroelectricity and lattice coupling in BaSnO3 and SrSnO3

The emergent intramolecular hydrogen bonding effect on the electronic structures of organic electron acceptors

The influence of polyanion molecular weight on polyelectrolyte multilayers at surfaces: protein adsorption and protein–polysaccharide complexation/stripping on natural polysaccharide films on solid supports

Front cover

Relativistic effects at the Cu2O2 core – a density functional theory study

Effects of TiCl4 treatment on the structural and electrochemical properties of a porous TiO2 layer in CH3NH3PbI3 perovskite solar cells

How many surface atoms in Co3O4 take part in oxygen evolution? Isotope labeling together with differential electrochemical mass spectrometry

Surface cleaning of artworks: structure and dynamics of nanostructured fluids confined in polymeric hydrogel networks

こちらもおすすめ

間溴苯甲酰腈の市場動向や研究トレンドはどうですか？

去磺基萝卜硫苷とは何ですか？

Methyl 2-amino-5-(trifluoromethyl)benzoateに適用される法規ガイドラインは何ですか？

3-ブロモ-1,3,4,5-四水化-2H-1-ベンザアゼピン-2-オンは安全ですか？

三氟甲基ピリジン-2-甲アミン塩酸塩は安全ですか？

1-エチル-4-(4-硝基フェニル)ピペリジンは安全ですか？

1,1-ジメトキシプロパン-2-オンは安全ですか？

コバルト(II) 3,3'-{[(1S,2S)-1,2-ジメチルフENCYCLICALE-1,2-エチエンジイル]ビス[ニトロリルメチルイリデン]}ビス[4-オキソ-2-ペンテン-2-olate]について「に適用される法規ガイドラインは何ですか？

「カーバミル酸, N-[8-[[2-[[2-(2,6-ジオキソ-3-ピペリジニル)-2,3-ジオキソ-1,3-ジヒドロ-1H-イソイソインドール-4-イルオキシ]アセチル]アミノ]オクチル]-1,1-ジメチレチルエステル」はどのように保存すればよいですか？

FMoc-D-4-Aph(tBu-CbM)-OHはどのように保存すればよいですか？

掲載誌

Organic & Biomolecular Chemistry

おすすめ化合物

Tris(2,2,3,3,4,4,5,5-octafluoropentyl) phosphate

N,O-Diacetyl-L-tyrosine

12-bromododecanoic acid

(1S,4aR,5R,7S,7aS)-1-(beta-D-Glucopyranosyloxy)-5-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl alpha-D-galactopyranoside

5-Methoxy-1H-pyrrolo[3,2-b]pyridine

おすすめサプライヤー