Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts

文献情報

出版日 2018-11-01

DOI 10.1039/C8OB02484G

インパクトファクター 3.876

著者

Weihua Li, Yifeng Wang, Danqian Xu

原文を見る

要旨

A highly enantioselective nucleophilic addition of ketones to imines catalyzed by chiral phase-transfer catalysts (N-quaternised cinchona alkaloid ammonium salts) has been developed, and the process affords the Mannich reaction products with tertiary stereocenters in good to high yields (up to 95%) with excellent enantioselectivities (up to 97% ee).

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts

文献情報

おすすめジャーナル

関連文献

A theoretical study on the electronic, structural and optical properties of armchair, zigzag and chiral silicon–germanium nanotubes

NMR study on the cellulose dissolution mechanism in CaCl2·6H2O–LiCl molten salt hydrate

Effect of curing reaction types on the structures and properties of acetylene-containing thermosets: towards optimization of curing procedure

Molecular insights into the binding variance of the SARS-CoV-2 spike with human, cat and dog ACE2 proteins

Spectroscopic investigations of electron and hole dynamics in MAPbBr3 perovskite film and carrier extraction to PEDOT hole transport layer

Triangular boron carbon nitrides: an unexplored family of chromophores with unique properties for photocatalysis and optoelectronics

Novel organic semiconductors based on 2-amino-anthracene: Synthesis, charge transport and photo-conductive properties

Investigation of the thermal decomposition mechanism of glycerol: the combination of a theoretical study based on the Minnesota functional and experimental support

Review on physical impedance models in modern battery research

Self-assembled, optically-active {naphthalene diimide}U{cucurbit[8]uril} ensembles in an aqueous environment

こちらもおすすめ

3-イチチルビフェニルはどのように合成されますか？

8-溴-5-三氟甲基喹啉はどのように合成されますか？

ジメチル4-(4,4,5,5-テトラメチル-1,3,2-ドioxaborolan-2-基)-2,6-ピリジンジカルボイル酸フェニルアミニドの代替品はありますか？

N-(3,5-ヘキサクロロ-4-ピリドインイル)-8-メチオキシ-5-キノリンカーボン酸の市場動向や研究トレンドはどのようなものでしょうか？

イソステアロイルグリセリルは安全ですか？

1-(二苯甲基)-3,3-二氟-氮杂环丁烷の市場動向や研究トレンドはどうですか？

3-チオフェンスチオールの物理化学的性質は何ですか？

2-Methyl-2-propanyl (2S)-2-(aminomethyl)-1-piperidinecarboxylateは安全ですか？

CAS番号1316822-90-8の化合物は安全ですか？

Tert-butyl 2-(2-羟基乙基)哌嗪-1-羧酸はどのように保存すればよいですか？

掲載誌

Organic & Biomolecular Chemistry

おすすめ化合物

1,4-Bis(bromomethyl)-2,5-dichlorobenzene

Benzyl 6-oxo-3,6-dihydro-1(2H)-pyridinecarboxylate

PS 1145 Dihydrochloride

N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (1:1)

1,10-bis(3,5-dimethylphenyl)-12-hydroxy-4,5,6,7-tetrahydroiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocine 12-oxide

おすすめサプライヤー