Rhodium-catalyzed regioselective C8-H amination of quinoline N-oxides with trifluoroacetamide at room temperature

文献情報

出版日 2018-06-04

DOI 10.1039/C8OB01108G

インパクトファクター 3.876

著者

Chang You, Tingting Yuan, Yanzhen Huang, Chao Pi, Yangjie Wu, Xiuling Cui

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要旨

A facile and efficient protocol for rhodium-catalyzed amination of quinoline N-oxides at the C-8 position using simple and commercially available trifluoroacetamide as the amino source has been developed, which proceeds with perfect regioselectivity at room temperature and short reaction times. This catalytic system is highly convenient on a gram scale. The desired products feature diverse functional group tolerance with good to excellent yields.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Rhodium-catalyzed regioselective C8-H amination of quinoline N-oxides with trifluoroacetamide at room temperature

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