Glutathione-driven Cu(i)–O2 chemistry: a new light-up fluorescent assay for intracellular glutathione

文献情報

出版日 2018-04-25

DOI 10.1039/C8AN00704G

インパクトファクター 4.616

著者

Peng Fei Gao, Yu Ting Mao, Tong Yang, Hong Yan Zou, Yuan Fang Li

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要旨

Besides its widely known role as an endogenous antioxidant in scavenging free radicals, glutathione (GSH) can also play the role of prooxidant and promote CuO-induced formation of hydroxyl radicals to light up a fluorescent signal through Cu(I)–O2 chemistry without requiring additional H2O2. This approach is independent of the mechanisms of enzyme mimics, such as the well-known oxidase and peroxidase mimetics, providing a new method to simply and effectively analyze intracellular GSH.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

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Glutathione-driven Cu(i)–O2 chemistry: a new light-up fluorescent assay for intracellular glutathione

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