A coumarin-based fluorescent probe for monitoring labile ferrous iron in living systems

文献情報

出版日 2018-04-24

DOI 10.1039/C8AN00556G

インパクトファクター 4.616

著者

Lingliang Long, Ning Wang, Yuanyuan Han, Meiyu Huang, Xiangqi Yuan, Siyu Cao, Aihua Gong, Kun Wang

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要旨

Labile Fe2+ has been considered to be a metabolically active and regulatory form of cellular iron. Monitoring the dynamic level of labile Fe2+ in biological systems is vital for evaluating the iron related biological processes and diseases as well as dissecting the exact physiological and pathophysiological functions of the labile Fe2+. Herein, we rationally constructed a coumarin-based fluorescent probe for sensing labile Fe2+ in living systems based on a novel Fe2+ meditated cyclization reaction strategy. The probe showed a highly selective and sensitive response to Fe2+, and the detection limit was determined to be 45 nM. Significantly, the probe displayed fast response to Fe2+, with the sensing reaction completed in 2 min, which is beneficial for real time sensing. The application of the probe for sensing different concentrations of labile Fe2+ in living cells has been conducted. In addition, the basal and endogenous levels of labile Fe2+ in living systems were also successfully monitored.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

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A coumarin-based fluorescent probe for monitoring labile ferrous iron in living systems

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