Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)

文献情報

出版日 2018-04-09

DOI 10.1039/C8AN00258D

インパクトファクター 4.616

著者

L. M. Frensemeier, J. Mayr, G. Koellensperger, B. K. Keppler, C. R. Kowol, U. Karst

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要旨

Pt(IV) prodrugs are a class of promising anticancer agents, which are activated by reduction to the active Pt(II) species. Consequently, the reduction process is a crucial parameter. Herein, a new approach using electrochemistry (EC) coupled to liquid chromatography (LC) and electrospray ionization-mass spectrometry (ESI-MS) or inductively coupled plasma (ICP)-MS was applied. This enabled getting insights into the differences in the reduction and ligand release of platinum(IV) complexes with varying equatorial core structures.

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CiteScore: 7.8

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年間論文数: 653

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Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)

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