A route to diastereomerically pure phenylglycine thioester peptides: crucial intermediates for investigating glycopeptide antibiotic biosynthesis

文献情報

出版日 2018-02-09

DOI 10.1039/C7CC09409D

インパクトファクター 6.222

著者

Madeleine Peschke, Clara Brieke

原文を見る

要旨

Non-ribosomal peptides contain an array of amino acid building blocks that can present challenges for the synthesis of important intermediates. Here, we report the synthesis of glycopeptide antibiotic (GPA) thioester peptides that retains the crucial stereochemical purity of the terminal phenylglycine residue, which we show is essential for the enzymatic GPA cyclisation cascade.

掲載誌

Chemical Communications

CiteScore: 8.6

自己引用率: 4.7%

年間論文数: 2458

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

A route to diastereomerically pure phenylglycine thioester peptides: crucial intermediates for investigating glycopeptide antibiotic biosynthesis

文献情報

おすすめジャーナル

関連文献

Exploring the charge reactions in a Li–O2 system with lithium oxide cathodes and nonaqueous electrolytes

Symmetry of octa-coordination environment has a substantial influence on dinuclear TbIII triple-decker single-molecule magnets

The synthesis, chain-packing simulation and long-term gas permeability of highly selective spirobifluorene-based polymers of intrinsic microporosity

Probing nucleus-enriched proteins in single living cells via a subcellular-resolved plasmonic immunosandwich assay‡

A novel hydrate of α-cyclodextrin crystallised under high-pressure conditions

Photoresponsive smart template for reversible cell micropatterning

A comparison of electron density from Hirshfeld-atom refinement, X-ray wavefunction refinement and multipole refinement on three urea derivatives

A ratiometric fluorescence strategy based on polyethyleneimine surface-modified carbon dots and Eosin Y for the ultrasensitive determination of protamine and trypsin

Front cover

A flexible rechargeable zinc-ion wire-shaped battery with shape memory function

こちらもおすすめ

（S）-四氢呋喃-3-羧酸の物理化学的性質は何ですか？

塩基性硫黄化合物1,3-ジメチル-1-[5-(三氟甲基)-1,3,4-硫杂环己二酮-2-基]尿素を含む廃棄物はどのように処理すべきですか？

インドリジン-2-カルボン酸は安全ですか？

5-甲基-2-(3-ピリジニル)-1,3-テイゾール-4-オールの市場動向や研究トレンドはどうですか？

4,4',4''-(嘧啶-2,4,6-三基)三苯甲醛はどのように保存すればよいですか？

（3aR）-1,3,3-トリフェニルテトラヒドロ-3H-ピロロ[1,2-c][1,3,2]-オキザボロロールについて、適用される法規ガイドラインは何ですか？

N,N-ジブチルプロパニジアミンの主な用途は何ですか？

6-(4-氯苯氧基)吡啶-3-胺の代替品はありますか？

4-甲基伞形酮硬脂酸酯は安全ですか？

3-フェニル-3,4-ジヒドロ-2H-1,4-ベンゾキサジンを取り扱う際の実験室安全事項は何ですか？

掲載誌

Chemical Communications

おすすめ化合物

4-Nitro-1,2-benzenediamine hydrochloride (1:1)

4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione

Potassium Phenylacetate

Sodium 6-amino-3-[(E)-{4-[(E)-(4-aminophenyl)diazenyl]-2-methoxy-5-methylphenyl}diazenyl]-4-hydroxy-2-naphthalenesulfonate

Imidazo[1,5-a]pyrazine

おすすめサプライヤー