A narrow open tubular column for high efficiency liquid chromatographic separation

文献情報

出版日 2018-03-15

DOI 10.1039/C7AN02065A

インパクトファクター 4.616

著者

Huang Chen, Yu Yang, Zhenzhen Qiao, Piliang Xiang, Jiangtao Ren, Yunzhu Meng, Kaiqi Zhang, Joann Juan Lu, Shaorong Liu

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要旨

We report a great feature of open tubular liquid chromatography when it is run using an extremely narrow (e.g., 2 μm inner diameter) open tubular column: more than 10 million plates per meter can be achieved in less than 10 min and under an elution pressure of ca. 20 bar. The column is coated with octadecylsilane and both isocratic and gradient separations are performed. We reveal a focusing effect that may be used to interpret the efficiency enhancement. We also demonstrate the feasibility of using this technique for separating complex peptide samples. This high-resolution and fast separation technique is promising and can lead to a powerful tool for trace sample analysis.

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Analyst

CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

A narrow open tubular column for high efficiency liquid chromatographic separation

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