Cobalt-catalyzed synthesis of quinolines from the redox-neutral annulation of anilides and alkynes

文献情報

出版日 2016-03-17

DOI 10.1039/C6QO00059B

インパクトファクター 5.281

著者

Qiangqiang Yan, Zhengkai Chen, Zhanxiang Liu

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要旨

A new method of cobalt-catalyzed annulation of anilides and internal alkynes for the efficient synthesis of quinoline scaffolds was developed. The combination of cobalt catalyst with the Lewis acid Zn(OTf)2 ensured the success of the annulation to give the quinoline heterocycles in high efficiency. The transformation is supposed to undergo ortho C–H activation and nucleophilic addition of C–Co species toward the amides. Attractive features of this system include the use of a low cost cobalt catalyst, the easy-handling operation, and readily available substrates.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Cobalt-catalyzed synthesis of quinolines from the redox-neutral annulation of anilides and alkynes

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