The origin of cooperative solubilisation by hydrotropes

文献情報

出版日 2016-09-05

DOI 10.1039/C6CP04823D

インパクトファクター 3.676

著者

Seishi Shimizu

原文を見る

要旨

The signature of hydrotropic solubilisation is the sigmoidal solubility curve; when plotted against hydrotrope concentration, solubility increases suddenly after the minimum hydrotrope concentration (MHC), and reaches a plateau at higher hydrotrope concentrations. This sigmoidal curve is characteristic of cooperative phenomena, yet the true molecular basis of hydrotropic cooperativity has long remained unclear. Here we develop a theory, derived from the first principles of statistical thermodynamics using partially-open ensembles, to identify the origin of hydrophobic cooperativity. Our theory bears a close resemblance to the cooperative binding model used for protein–ligand binding. The cause of cooperativity is the enhancement of the hydrotrope m-body interaction induced by the presence of the solute; m can be estimated from the experimental solubility data.

掲載誌

Physical Chemistry Chemical Physics

CiteScore: 5.5

自己引用率: 10.3%

年間論文数: 3036

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