Phase transitions in hydrophobe/phospholipid mixtures: hints at connections between pheromones and anaesthetic activity

文献情報

出版日 2016-05-06

DOI 10.1039/C6CP00659K

インパクトファクター 3.676

著者

Silvia Borsacchi, Marco Geppi, Sara Macchi, Emiliano Fratini, Moira Ambrosi

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要旨

The phase behavior of a mixture of a typical insect pheromone (olean) and a phospholipid (DOPC)/water dispersion is extensively explored through SAXS, NMR and DSC experiments. The results mimic those obtained with anaesthetics in phospholipid/water systems. They also mimic the behavior and microstructure of ternary mixtures of a membrane mimetic, bilayer-forming double chained surfactants, oils and water. Taken together with recent models for conduction of the nervous impulse, all hint at lipid involvement and the underlying unity in mechanisms of pheromone, anaesthetic and hydrophobic drugs, where a local phase change in the lipid membrane architecture may be at least partly involved in the transmission of the signal.

掲載誌

Physical Chemistry Chemical Physics

CiteScore: 5.5

自己引用率: 10.3%

年間論文数: 3036

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