Graphene oxide-based electrochemical label-free detection of glycoproteins down to aM level using a lectin biosensor

文献情報

出版日 2016-05-31

DOI 10.1039/C6AN00793G

インパクトファクター 4.616

著者

L. Klukova, J. Filip, S. Belicky, A. Vikartovska, J. Tkac

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要旨

A label-free ultrasensitive impedimetric biosensor with lectin immobilised on graphene oxide (GO) for the detection of glycoproteins from 1 aM is shown here. This is the first time a functional lectin biosensor with lectin directly immobilised on a graphene-based interface without any polymer modifier has been described. The study also shows that hydrophilic oxidative debris present on GO has a beneficial effect on the sensitivity of (8.46 ± 0.20)% per decade for the lectin biosensor compared to the sensitivity of (4.52 ± 0.23)% per decade for the lectin biosensor built up from GO with the oxidative debris washed out.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Graphene oxide-based electrochemical label-free detection of glycoproteins down to aM level using a lectin biosensor

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