DNA tetrahedron and star trigon nanostructures for target recycling detection of nucleic acid

文献情報

出版日 2016-05-04

DOI 10.1039/C6AN00762G

インパクトファクター 4.616

著者

Xifeng Chen, Bidou Wang, Guangxing Liu, Yuguo Tang, Peng Miao

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要旨

Human immunodeficiency virus (HIV) is a retrovirus which attacks the human body's immune system and further leads to acquired immunodeficiency syndrome (AIDS). Nucleic acid detection is of great importance in the medical diagnosis of such diseases. Herein, we develop a simple and enzyme-free electrochemical method for the target recycling detection of nuclei acid. DNA tetrahedron and star trigon nanostructures are designed and constructed on the electrode interface for target capture and signal enrichment. This strategy is convenient and sensitive, with a limit of detection as low as 1 fM, and can also successfully distinguish single-base mismatched DNA. Therefore, the proposed method has a promising potential application for HIV DNA detection.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

DNA tetrahedron and star trigon nanostructures for target recycling detection of nucleic acid

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