Continuous flow Buchwald–Hartwig amination of a pharmaceutical intermediate
文献情報
Polina Yaseneva, Paul Hodgson, Jacek Zakrzewski, Sebastian Falß, Rebecca E. Meadows, Alexei A. Lapkin
A flow process for direct amination of a pharmaceutically relevant substrate using a Pd-NHC based catalyst was demonstrated in a lab-scale mini-plant and in a pilot-scale plant. The lab-scale mini-plant was used to determine catalyst stability under recycling conditions. Results in the mini-plant have shown the maximum space–time yield between the three types of reactor systems: a batch reactor, a mini-plant and a pilot plant. A comprehensive life-cycle assessment study of the synthesis of organometallic catalysts and their impact on the overall LCA of flow vs. batch syntheses was developed. Combined with a simplified economic analysis, the LCA study confirmed the benefits of switching to flow.
おすすめジャーナル
関連文献
Kinetic analysis of supported Ni-catalyzed CO2/CH4 reactions using photoacoustic spectroscopy
Ji-Woong Kim, Jae-Au Ha, Hun Jung, Byung-II Ahn, Sung-Han Lee, Joong-Gill Choi
DOI: 10.1039/B709102H
Investigations on the gas-phase photolysis and OH radical kinetics of methyl-2-nitrophenols
Ian Barnes, Romeo Olariu, Shouming Zhou, Peter Wiesen, Thorsten Benter
DOI: 10.1039/B709464G
Physico-chemical and structural properties of hydrogels formed by chitosan, in the presence and absence of poly(vinylpyrrolidone) and sodium decylsulfate
Henrich Frielinghaus
DOI: 10.1039/B710143K
Transient behavior of an electrolytic diode
Zdeněk Slouka, Michal Přibyl, Dalimil Šnita, Tomáš Postler
DOI: 10.1039/B707197C
How realistic is the pore size distribution calculated from adsorption isotherms if activated carbon is composed of fullerene-like fragments?
Artur P. Terzyk, Sylwester Furmaniak, Peter J. F. Harris, Piotr A. Gauden, Jerzy Włoch, Piotr Kowalczyk, Gerhard Rychlicki
DOI: 10.1039/B710552E
The canonical and other mechanisms of elementary chemical reactions
Jesús Aldegunde, F. Javier Aoiz, Vicente Sáez-Rábanos, Brian K. Kendrick, Marcelo P. de Miranda
DOI: 10.1039/B707190F
Low-volatility poly-oxygenates in the OH-initiated atmospheric oxidation of α-pinene: impact of non-traditional peroxyl radical chemistry
L. Vereecken, J.-F. Müller, J. Peeters
DOI: 10.1039/B708023A
Structures and energetics of 98 atom Pd–Pt nanoalloys: potential stability of the Leary tetrahedron for bimetallic nanoparticles
Lauro Oliver Paz-Borbón, Thomas V. Mortimer-Jones, Roy L. Johnston, Alvaro Posada-Amarillas, Giovanni Barcaro, Alessandro Fortunelli
DOI: 10.1039/B707136A
こちらもおすすめ
1-{3-[5-(エチルカルボンイル)-2,4-ジメチル-1H-ピロロール-3-基]プロパニル}ピペリジン-4-カルボン酸について、適用される法規ガイドラインは何ですか?
この化合物はCAS番号1142209-81-1であり、GHS分類では corrosive (腐食性物質) と classified (分類物質) として指定され...
2,2-二氟-1,3-ベンゾジオキサン-5-カルボキシlic酸とは何ですか?
2,2-二氟-1,3-ベンゾジオキサン-5-カルボキシlic酸は、CAS番号656-46-2の化合物で、化学式はC8H4F2O4です。この化合物は白色の結晶性粉...
8-氯-4-色原酮の代替品はありますか?
8-氯-4-色原酮(CAS番号: 49701-11-3)の代替品には、他の色原酮類似物や、構造が似ている化合物があります。例えば、8-メチル-4-色原酮や、他の...
エチル6,6-ジメチル-4,5,6,7-テトラヒドロ-1H-インドアゼー-3-カルボキシレートとは何ですか?
エチル6,6-ジメチル-4,5,6,7-テトラヒドロ-1H-インドアゼー-3-カルボキシレートは、CAS番号1233243-56-5を有する化合物です。これは有...
4-叔丁基-6-氯-嘧啶に適用される法規ガイドラインは何ですか?
4-叔丁基-6-氯-嘧啶はCAS番号3435-24-3で、GHS分類では毒性物質とみなし、GHSの危険性分類が適用されます。REACH規則では登録が必要で、Eu...
維库溴铵杂质Bはどのように合成されますか?
維库溴铵杂质Bは、アンドロステンデンから始まり、一連の合成反応、包括的な選択性と高い収率で合成されます。具体的には、ブロミド化、酸化、ジマーゼ反応、アミド化など...
2-(4-氟苄基)-吡咯烷の物理化学的性質は何ですか?
CAS番号350017-04-8の2-(4-氟苄基)-吡咯烷は、結晶性の白色粉末です。分子量は199.17 g/molで、水に溶けにくいです。化学反応では比較的...
3-喹啉甲醛(2-チロール-8-エチル)は安全ですか?
3-喹啉甲醛(2-チロール-8-エチル)は一定の毒性を持つため、取扱には注意が必要です。使用する際は適切な防護具を着用し、密閉容器で保管・搬送し、直接的な接触を...
エチル3-(ヒドロキシメチル)-1H-ピロール-2-カルボキシレートはどのように保存すればよいですか?
エチル3-(ヒドロキシメチル)-1H-ピロール-2-カルボキシレートは、室温(25℃)以下で保存し、直射日光を避け、乾燥した環境で保管することが推奨されます。ま...
掲載誌
Reaction Chemistry & Engineering

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.












![3-[(4-Nitrobenzyl)oxy]-3-oxopropanoic Acid structure 3-[(4-Nitrobenzyl)oxy]-3-oxopropanoic Acid structure](https://static.chemtradehub.com/structs/773/77359-11-6-0d04.webp)

