Enantioselective nickel-catalyzed alkylative alkyne–aldehyde cross-couplings

文献情報

出版日 2015-07-23

DOI 10.1039/C5QO00148J

インパクトファクター 5.281

著者

Ming Nie, Wenzhen Fu, Ziping Cao, Wenjun Tang

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要旨

An efficient asymmetric nickel-catalyzed alkylative alkyne–aldehyde cross-coupling is developed by employing a P-chiral monophosphorus ligand BI-DIME, allowing rapid access to a series of chiral tetra-substituted olefinic allylic alcohols in high yields and good to excellent ees. The three-component reactions enjoy excellent regio- and enantioselectivities, and a broad substrate scope from readily available starting materials.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Enantioselective nickel-catalyzed alkylative alkyne–aldehyde cross-couplings

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