Facile synthesis of drug-conjugated PHPMA core-crosslinked star polymers

文献情報

出版日 2015-05-13

DOI 10.1039/C5PY00497G

インパクトファクター 5.582

著者

Bryan S. Tucker, Stephen G. Getchell, Megan R. Hill, Brent S. Sumerlin

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要旨

Poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA), a biocompatible and non-immunogenic polymer, was used to form core-crosslinked star polymers for potential drug delivery applications. The conditions for the formation of the PHPMA stars were studied by varying the molecular weight of the PHPMA unimers, [crosslinker] : [unimer] ratios, and solvent. The optimized conditions were then used to form drug-loaded PHPMA star polymers by directly copolymerizing an HPMA-modified anticancer drug, methotrexate, during the crosslinking reaction of PHPMA unimers. The incorporation of the drug was confirmed by 1H NMR spectroscopy, and UV-visible spectroscopy was used to determine a drug loading of 20 wt%. Our initial drug release studies showed that the addition of an esterase induced drug release.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Facile synthesis of drug-conjugated PHPMA core-crosslinked star polymers

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