NIR-responsive polypeptide copolymer upconversion composite nanoparticles for triggered drug release and enhanced cytotoxicity
文献情報
Gang Liu, Na Liu, Linzhu Zhou, Yue Su, Chang-Ming Dong
Near infrared (NIR) light-responsive polymeric nanomedicines might achieve spatiotemporal, pulsatile, and on-demand drug release profiles and are appealing as a noninvasive technology for various clinical therapies. Polypeptide copolymer composite nanoparticles with different amounts of upconversion nanoparticles (UCNPs) were successfully fabricated in aqueous solution, and the NIR sensitivity of the composite nanoparticles was characterized by time-resolved UV-vis spectroscopy, on-line dynamic light scattering, and transmission electron microscopy. The composite nanoparticles disassembled with the help of UCNPs converting NIR light into UV light, and the NIR-responsive time can be tuned by both the loaded amount of UCNPs and the polypeptide chain length. The composite nanoparticles loaded with the anticancer drug doxorubicin (DOX) can release DOX in a controllable and/or pulsatile manner, and the drug release profile can be manipulated by NIR light. The DOX-loaded composite nanoparticles can be quickly internalized by HeLa cells and then release DOX inside the cells, as evidenced by flow cytometry and confocal laser scanning microscopy. After 5 or 10 min of NIR irradiation, the half maximal inhibitory concentration (IC50) for the DOX-loaded composite nanoparticles dropped to 5.08 μg DOX equiv. mL−1 or 2.95 μg DOX equiv. mL−1, respectively, compared to 8.26 μg DOX equiv. mL−1 for the non-irradiated sample, demonstrating a tunable NIR-triggered cytotoxicity. This work provides a versatile platform for the fabrication of NIR-responsive polypeptide copolymer nanomedicines with the potential for on-demand drug delivery and cancer therapy.
関連文献
Exceptionally high H2storage by a metal–organic polyhedral framework
Yong Yan, Xiang Lin, Sihai Yang, Alexander J. Blake, Anne Dailly, Neil R. Champness, Peter Hubberstey, Martin Schröder
DOI: 10.1039/B900013E
3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters
Jaskiranjit Kang, Jonathan P. Richardson, Derek Macmillan
DOI: 10.1039/B815888F
Single amino acid chelates (SAAC): a strategy for the design of technetium and rhenium radiopharmaceuticals
Mark Bartholomä, John Valliant, Kevin P. Maresca, John Babich, Jon Zubieta
DOI: 10.1039/B814903H
Nanocrystals of [Cu3(btc)2] (HKUST-1): a combined time-resolved light scattering and scanning electron microscopy study
Denise Zacher, Jianing Liu, Klaus Huber, Roland A. Fischer
DOI: 10.1039/B819580C
Bisbenzimidazole to benzobisimidazole: from binding B-form duplex DNA to recognizing different modes of telomereG-quadruplex
Jing Huang, Guorui Li, Zhiguo Wu, Zhibin Song, Yangyang Zhou, Liang Shuai, Xiaocheng Weng, Xiang Zhou, Guangfu Yang
DOI: 10.1039/B819789J
Direct enantioselectivealdol reactions catalyzed by a proline–thiourea host–guest complex
Ömer Reis, Serkan Eymur, Barbaros Reis, Ayhan S. Demir
DOI: 10.1039/B817474A
Novel ⊕N(←L)2 species with two lone pairs on nitrogen: systems isoelectronic to carbodicarbenes
Dhilon S. Patel, Prasad V. Bharatam
DOI: 10.1039/B816595E
Directed covalent assembly of rigid organic nanodisks using self-assembled temporary scaffolds‡
Samuel Tekobo, Eugene Pinkhassik
DOI: 10.1039/B817598E
The importance of surface chemistry in mesoporous materials: lessons from porous silicon biosensors
Kristopher A. Kilian, Till Böcking, J. Justin Gooding
DOI: 10.1039/B815449J
The biomimeticmineralization of double-stranded and cylindrical helical BaCO3nanofibres
Jian-Hua Zhu, Shu-Hong Yu, An-Wu Xu, Helmut Cölfen
DOI: 10.1039/B817048G
こちらもおすすめ
オステニ二甲磺酸塩に適用される法規ガイドラインは何ですか?
オステニ二甲磺酸塩は、GHS分類に基づき corrosive 物質として分類されます。REACH規則では、該当物質の登録が要求される可能性があります。また、FD...
環丁基肼盐酸盐は安全ですか?
環丁基肼盐酸盐は毒性があり、吸入や皮膚接触は有害です。使用時の安全対策として、密閉システムを使用し、適切な排気設備を備えた場所で作業することが推奨されます。
N-(4-パリドン基ソニルフェニル)硫代イソシアネートを取り扱う際の実験室安全事項は何ですか?
N-(4-パリドン基ソニルフェニル)硫代イソシアネートは高毒性で、皮膚や吸入による毒性があります。取り扱う際は防毒マスク、保護用手袋、保護眼鏡などのPPEを着用...
5-ヒドロキシ-1,3-ジヒドロ-2H-インドン-2-酮の物理化学的性質は何ですか?
CAS番号3416-18-0の5-ヒドロキシ-1,3-ジヒドロ-2H-インドン-2-酮は、結晶性の白色粉末です。分子量は228.25であり、 aqueous m...
O-苄基-D-丝氨醇はどのように合成されますか?
O-苄基-D-丝氨醇は、D-アミノ酸とベンゼン環の経由で合成されます。触媒としてジメチルアミノピリジンが使用され、選択性は高いです。一般的な収率は約90%です。
ナトリウム3-ヒドロキシbutano酸とは何ですか?
ナトリウム3-ヒドロキシbutano酸は、CAS番号13613-65-5で登録されている化合物です。この化合物は、(3R)-3-ヒドロキシbutano酸とナトリ...
1-(二苯甲基)-4-甲基ベンゼンの物理化学的性質は何ですか?
CAS番号603-37-2の1-(二苯甲基)-4-甲基ベンゼンは、結晶性の固体で、分子量は244.28であり、水中的には微溶です。この化合物は有機反応において中...
ネアミン塩酸塩の物理化学的性質は何ですか?
ネアミン塩酸塩の分子量は321.19であり、結晶性の白色粉末です。この化合物は水に溶けやすく、pHが低くなると不溶性になります。反応活性は高く、水溶液中の酸化還...
偶氮二甲酰二哌啶の主な用途は何ですか?
偶氮二甲酰二哌啶は、医薬品、染料、高 Então 剤、触媒、溶媒、量論試薬など、様々な分野で使用されています。特に、高 Enough 反応において、グリコール酸...
掲載誌
Polymer Chemistry

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.














