Poly(thiolactone) homo- and copolymers from maleimide thiolactone: synthesis and functionalization

文献情報

出版日 2015-04-30

DOI 10.1039/C5PY00329F

インパクトファクター 5.582

著者

Pieter Espeel, Filip E. Du Prez

原文を見る

要旨

We describe the synthesis of a thiolactone-functionalized maleimide (MITla), and its (co)polymerization into poly(thiolactone) homo- and copolymers via controlled or free radical polymerization (CRP or FRP) techniques. Homopolymers were synthesized using FRP whereas MITla was copolymerized with styrene and N-iso-propylacrylamide (NIPAAm) via RAFT. In that way, we were able to combine the properties of a maleimide with the possibility to use the thiolactone side chain functionality in subsequent double modification reactions. Thiolactones are susceptible to nucleophilic ring-opening in the presence of primary amines, releasing a thiol moiety that can be used for conjugate addition (nucleophilic thiol–ene) reactions afterwards. We synthesized and characterized copolymers of different compositions, followed by site-specific double modification reactions with a combination of n-butylamine and methyl acrylate.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Poly(thiolactone) homo- and copolymers from maleimide thiolactone: synthesis and functionalization

文献情報

おすすめジャーナル

関連文献

Mass spectrometry-based quantitation combined with time-dependent metabolomics to discover metabolic features in human neurogenesis using neural constructs generated from neural progenitor cells

Comparison between one and two-dimensional liquid chromatographic approaches for the determination of plasmatic stroke biomarkers by isotope dilution and tandem mass spectrometry

A molecularly imprinted electrochemical sensor for specific and ultrasensitive determination of an aminoglycoside drug: the role of copper ions in the determination

Silent Raman imaging of highly effective anti-bacterial activity synchronous with biofilm breakage using poly(4-cyanostyrene)@silver@polylysine nanocomposites

Development of a modularized aptamer targeting the nuclear T-cell suppressor PAC1

Surface plasmon resonance detection of UV irradiation-induced DNA damage and photoenzymatic repair processes through specific interaction between consensus double-stranded DNA and p53 protein

Suppressed DNA base pair stacking assembly of gold nanoparticles in an alcoholic solvent for enhanced ochratoxin A detection in Baijiu

An electrochemiluminescence aptasensor based on highly luminescent silver-based MOF and biotin–streptavidin system for mercury ion detection

Solvent-regulated fluorescence off–on signaling of Ni(ii) and Zn(ii) with the formation of two mononuclear complexes with an ATP detection ability by Zn(ii) assembly

Overview and considerations in bottom-up proteomics

こちらもおすすめ

除水剤ALT-201は安全ですか？

「邻羟基阿托伐他汀内酯标准品」に適用される法規ガイドelinesは何ですか？

メチル（3R）-3-アミノ-2,3-ジヒドロ-1-ベンゾファンラニン-5-カルボイル酸塩塩酸塩の主な用途は何ですか？

トランス-4-メチルピロリジン-3-オール塩酸塩はどのように合成されますか？

硫雜環丁烷-1,1-二氧化物は安全ですか？

ブラエリリンの主な用途は何ですか？

9-ヒドロキシエリプチシネ塩酸塩はどのように合成されますか？

5-塩素-2-(メチルアミノ)フェニル-(2-塩素フェニル)メタン酮の物理化学的性質は何ですか？

1-[2-(4-甲氧基-苯氧基)-乙基]-哌嗪はどのように保存すればよいですか？

2-[3-(4-甲氧基フェニル)プロピル]-4,4,5,5-四メチル-1,3,2-ドイボロロールアンの主な用途は何ですか？

掲載誌

Polymer Chemistry

おすすめ化合物

cis-3-Amino-1-(trifluoromethyl)cyclobutanol hydrochloride (1:1)

[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Diacetyloxy-15-[(2R,3S)-3-benzamido-3-phenyl-2-(2,2,2-trichloroethoxycarbonyloxy)propanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

(2E)-3-(3-Chlorophenyl)-N-{2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl}acrylamide

1-(4-Methyl-2-thienyl)methanamine

N3-ethylpyridine-3,4-diamine

おすすめサプライヤー