Selective monoalkylation of amines with light electrophiles using a flow microreactor system

文献情報

出版日 2015-02-03

DOI 10.1039/C4QO00342J

インパクトファクター 5.281

著者

Thomas Lebleu, Jacques Maddaluno, Julien Legros

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要旨

The challenging direct monoalkylation of amines with light electrophilic reagents (C1 to C3) was performed through a flow microreactor approach. The efficiency of mixing coupled with short residence times (tR = 0.7–62 s) allows the transfer of a single alkyl group from R-OTf onto primary amines (R = Et, Pr) as well as on secondary amines (R = Me, Et, Pr, allyl, propargyl) with good selectivities.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Selective monoalkylation of amines with light electrophiles using a flow microreactor system

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