Selective monoalkylation of amines with light electrophiles using a flow microreactor system
文献情報
Thomas Lebleu, Jacques Maddaluno, Julien Legros
The challenging direct monoalkylation of amines with light electrophilic reagents (C1 to C3) was performed through a flow microreactor approach. The efficiency of mixing coupled with short residence times (tR = 0.7–62 s) allows the transfer of a single alkyl group from R-OTf onto primary amines (R = Et, Pr) as well as on secondary amines (R = Me, Et, Pr, allyl, propargyl) with good selectivities.
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