Retro-Claisen benzylation: direct use of benzyl alcohols in Pd-catalyzed couplings with nitriles
文献情報
Tapan Maji, Kinthada Ramakumar, Jon A. Tunge
A new strategy has been developed for the benzylation of nitriles directly from benzyl alcohols. In this process benzyl alcohols undergo retro-Claisen activation with cyanoacetic esters to generate an active electrophile and a carbanionic nucleophile. In the presence of Pd(0) these intermediates undergo catalytic coupling to generate a new C–C bond, resulting in the formation of phenyl propionitriles.
関連文献
The effect of hydration on the electronic structure and stability of the superalkali cation Li3+
Jia-Huan Hou, Di Wu, Jia-Yuan Liu, Si-Yi Li, Dan Yu, Ying Li
DOI: 10.1039/C8CP00862K
Binary mixtures of novel sulfoxides and water: intermolecular structure, dynamic properties, thermodynamics, and cluster analysis
DOI: 10.1039/C8CP04012E
Screening heteroatom distributions in zeotype materials using an effective Hamiltonian approach: the case of aluminogermanate PKU-9
Ricardo Grau-Crespo, Dewi W. Lewis, A. Rabdel Ruiz-Salvador
DOI: 10.1039/C8CP01369A
The evaporation kinetics of pure water droplets at varying drying rates and the use of evaporation rates to infer the gas phase relative humidity
Yong-yang Su, Rachael E. H. Miles, Zhi-ming Li, Jonathan P. Reid, Jiang Xu
DOI: 10.1039/C8CP05250F
Reply to the ‘Comment on “Spectroscopic properties and location of the Ce3+ energy levels in Y3Al2Ga3O12 and Y3Ga5O12 at ambient and high hydrostatic pressure”’ by Y. Wang, M. Głowacki, M. Berkowski, A. Kamińska and A. Suchocki, Phys. Chem. Chem. Phys., 2019, 21, DOI: 10.1039/C8CP06154H
Sebastian Mahlik, Agata Lazarowska, Jumpei Ueda, Setsuhisa Tanabe, Marek Grinberg
DOI: 10.1039/C8CP07122E
Most favorable cumulenic structures in iron-capped linear carbon chains are short singlet odd-carbon dications: a theoretical view
Liang Pu, Zhong Zhang, R. Bruce King, Wesley D. Allen
DOI: 10.1039/C7CP08673C
Insights into the complex interaction between hydrophilic nanoparticles and ionic surfactants at the liquid/air interface
Jingyu Jin, Xiaoyan Li, Jiafeng Geng, Dengwei Jing
DOI: 10.1039/C8CP01838C
A theoretical insight into a feasible strategy for the fabrication of borophane
Gangqiang Qin, Aijun Du, Qiao Sun
DOI: 10.1039/C8CP01407H
Constructing organic superacids from superhalogens is a rational route as verified by DFT calculations
Fu-Qiang Zhou, Ru-Fang Zhao, Jin-Feng Li, Wen-Hua Xu, Chao-Chao Li, Lan Luo, Jian-Li Li, Bing Yin
DOI: 10.1039/C8CP07313A
Percolation behaviors of ionic and electronic transfers in Li3−2xCoxN
E. Panabière, N. Emery, O. Dubrunfaut, J. P. Pereira-Ramos
DOI: 10.1039/C8CP06770H
こちらもおすすめ
4'-ブロモビフェニル-3-メトークシーディ.ActionBarはどのように保存すればよいですか?
4'-ブロモビフェニル-3-メトークシーディ.ActionBarは、冷暗所で、直射日光を避け、密栓の容器に保存し、遠隔場所に保管してください。温度は常温(0〜2...
2-異丙基フェニルヒドラジン塩酸塩とは何ですか?
2-異丙基フェニルヒドラジン塩酸塩は、CAS番号58928-82-8を有する化合物で、構造式はC11H14N2HClです。これは塩基性化合物であり、水に溶けやす...
5-(4-クロロフェニル)-4H-1,2,4-三氮唑-3-アミンを取り扱う際の実験室安全事項は何ですか?
5-(4-クロロフェニル)-4H-1,2,4-三氮唑-3-アミンは取り扱いに注意が必要です。PPEとして防塵マスク、ゴーグル、手袋を使用し、ドラフトチャンバーを...
去甲基雷贝拉唑硫醚はどのように合成されますか?
去甲基雷贝拉唑硫醚は、ベンジミダゾール硫化物と3-メチル-4-ピリジノールの反応によって合成されます。具体的には、2-チオキシドベンジミダゾールと3-メチル-4...
2-ブロモ-5-フロロ-N-(2-フェノールメチル)ベンゼンウレアは安全ですか?
2-ブロモ-5-フロロ-N-(2-フェノールメチル)ベンゼンウレアは、毒性や刺激性の実験データに基づき、適切な取扱いと防護措置を講じることで安全に使用できます。...
対甲苯磺酸酯-四聚乙二醇-四氢吡喃醚の物理化学的性質は何ですか?
対甲苯磺酸酯-四聚乙二醇-四氢吡喃醚のCAS番号は86259-89-4です。この化合物は無色の液体で、分子量は約724.8です。高濃度では溶血性が報告されており...
2-(3-(二氟甲基)-4-氟苯基)-4,4,5,5-四甲基-1,3,2-二噁硼戊環はどのように保存すればよいですか?
2-(3-(二氟甲基)-4-氟苯基)-4,4,5,5-四甲基-1,3,2-二噁硼戊環は、室温で暗い場所に保管し、直射日光から遠ざけ、容器は密閉状態で保存してくだ...
6-アミノ-5-クロロ-2-シクロプロピルピリミジンカルボン酸の代替品はありますか?
この化合物の代替品には、ピロリミジン酸やその類似物、またピロリミジンカルボン酸の他の異性体があります。これらの代替品は、特定の化学反応や目的に応じて選択すること...
5-クロロベンゾ[1,3]二オキセイン-4-アミンに適用される法規ガイドラインは何ですか?
5-クロロベンゾ[1,3]二オキセイン-4-アミンはCAS番号379228-45-2に該当します。この化合物はGHS分類でH314(接触により急性毒性がある)と...
掲載誌
Chemical Communications

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry










![4-Fluoro-2-(4-{[(3S,4R)-4-(2-hydroxy-2-propanyl)-3-pyrrolidinyl]amino}-6,7-dimethoxy-2-quinazolinyl)phenol hydrochloride (1:1) structure 4-Fluoro-2-(4-{[(3S,4R)-4-(2-hydroxy-2-propanyl)-3-pyrrolidinyl]amino}-6,7-dimethoxy-2-quinazolinyl)phenol hydrochloride (1:1) structure](https://static.chemtradehub.com/structs/143/1431697-96-9-619c.webp)

![5-Chloropyrrolo[2,1-f][1,2,4]triazin-4(3H)-one structure 5-Chloropyrrolo[2,1-f][1,2,4]triazin-4(3H)-one structure](https://static.chemtradehub.com/structs/888/888720-60-3-4f7c.webp)

