Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistry

文献情報

出版日 2013-05-22

DOI 10.1039/C3PY00364G

インパクトファクター 5.582

著者

Chaoliang He, Chunsheng Xiao, Jianxun Ding, Shuangjiang Yu, Xiuli Zhuang, Xuesi Chen

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要旨

This study aims to develop novel reduction-responsive cross-linked micelles (CMs) based on poly(ethylene glycol)-block-poly(γ-propargyl-L-glutamate) (PEG-PPLG) by click chemistry. 1H NMR spectroscopy, IR spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM) were performed to confirm the successful construction of the CMs. Doxorubicin (DOX) was loaded into the CMs as a model anticancer drug. The DOX-loaded CMs could hold the drug under physiological conditions, and release the payload quickly in the presence of glutathione (GSH). Confocal laser scanning microscopy (CLSM) and flow cytometry measurements revealed that the intracellular drug release from the DOX-loaded CMs was increased in the HeLa cells with an enhanced intracellular GSH level. In vitro methyl thiazolyl tetrazolium (MTT) assays indicated that the CMs were biocompatible, and DOX-loaded CMs showed higher cellular proliferation inhibition towards GSH-pretreated HeLa cells than non-pretreated cells. Due to their unique responsiveness, the biocompatible CMs show promise for the intracellular delivery of chemotherapeutic drugs in cancer therapy.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistry

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