Pluronic L61 as a long-circulating modifier for enhanced liposomal delivery of cancer drugs

文献情報

出版日 2013-03-27

DOI 10.1039/C3PY00042G

インパクトファクター 5.582

著者

Ergang Liu, Xiaoyi Sun, Pengyu Huang, Hao Long, Hua Wang, Xin Yu, Caihong Zheng

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要旨

Pluronic copolymer L61 was found to possess a stealth function for liposomal drug delivery, comparing favorably to PEG. The liposomes modified with 0.1% L61 (w/w) were long-circulating, and preferentially accumulated in the tumor site. The paclitaxel-loaded L61-liposomes with a single injection dose could successfully arrest the tumor growth, lasting for five days, and displayed better treatment outcomes compared to the non-modified liposomes and even the PEGylated liposomes.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Pluronic L61 as a long-circulating modifier for enhanced liposomal delivery of cancer drugs

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