PEGylated conjugated polyelectrolytes containing 2,1,3-benzoxadiazole units for targeted cell imaging

文献情報

出版日 2012-04-13

DOI 10.1039/C2PY20113E

インパクトファクター 5.582

著者

Jie Liu, Dan Ding, Junlong Geng, Bin Liu

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要旨

Two amphiphilic conjugated polyelectrolytes (CPEs) were designed and synthesized via a post-polymerization strategy. A neutral precursor polymer of poly(9,9-bis(6′-azidohexyl)fluorene-alt-2,1,3-benzoxadiazole) (PFBD-N3) was synthesized first through Suzuki polymerization, which was followed by click reaction to incorporate dense poly(ethylene glycol) (PEG) to afford PFBD-PEG600-COOH and PFBD-PEG2000-COOH, respectively. The CPEs show better solubility in water with increasing PEG chain length due to the increased hydrophilicity of longer PEG chains. Both CPEs formed nanoparticles (NPs) in water and were used as cellular probes for visualization of HT-29 cancer cells. As compared to PFBD-PEG600-COOH NPs, PFBD-PEG2000-COOH NPs were less efficiently taken up by cells due to the longer PEG side chains, which significantly inhibited nonspecific cellular uptake. Further conjugation of PFBD-PEG2000-COOH with c(RGDfK) yielded PFBD-PEG2000-RGD NPs as a specific cellular probe for targeted cancer cell imaging. Preliminary study revealed that PFBD-PEG2000-RGD NPs were favorable for targeted cellular imaging with low cytotoxicity, high selectivity and good photostability.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

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PEGylated conjugated polyelectrolytes containing 2,1,3-benzoxadiazole units for targeted cell imaging

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