Stealth macromolecular platforms for the design of MRI blood pool contrast agents

文献情報

出版日 2011-07-28

DOI 10.1039/C1PY00198A

インパクトファクター 5.582

著者

Mathurin Grogna, Rudi Cloots, André Luxen, Christine Jérôme, Catherine Passirani, Nolwenn Lautram, Jean-F. Desreux, Mike Collodoro, Marie-Claire De Pauw-Gillet, Christophe Detrembleur

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要旨

Stealth macromolecular platforms bearing alkyne groups and poly(ethylene oxide) brushes were synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization. The anchoring of Gd3+-chelates bearing an azide group was then carried out by the Huisgen 1,3-dipolar cycloaddition (“click”) reaction in mild conditions, leading to macrocontrast agents for MRI applications. The gadolinium complex is hidden in the PEO shell that renders the macrocontrast agents free of any cytotoxicity and stealth to proteins of the immune system. Relaxometry measurements have evidenced an improved relaxivity of the macrocontrast agent compared to ungrafted gadolinium chelate. Moreover, this relaxivity is further enhanced when the spacer length between the Gd3+-chelate and the polymer backbone is shorter, as the result of its decreased tumbling rate. These novel products are therefore promising candidates for MRI applications.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Stealth macromolecular platforms for the design of MRI blood pool contrast agents

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