Synthesis of glycosylated peptides by NCA polymerization for recognition of human T-cells

文献情報

出版日 2011-07-28

DOI 10.1039/C1PY00187F

インパクトファクター 5.582

著者

Thomas Stöhr, André-René Blaudszun, Ute Steinfeld, Gerhard Wenz

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要旨

Peracetylated sugars (glucose, mannose, galactose) were attached via a thiourea linker to the ε-amino group of α-BOC-lysine and α-Z-lysine. After transformation to the N-carboxyanhydride (NCA), the product was copolymerized with both PEGylated lysine-NCA and ε-TFA-lysine-NCA by both tertiary amine and nickel complex catalysts. The resulting statistical copolypeptides are water-soluble after global deprotection and show an α-helical secondary structure. Fluorescein isothiocyanate (FITC) was then coupled to the free ε-NH2 groups of the lysine repeating units. The galactosylated fluorescent peptides are specifically incorporated in human T lymphocytes at 37 °C, as shown by flow cytometry and fluorescence microscopy. Therefore they are potentially useful for selective staining of cells or targeted drug delivery.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Synthesis of glycosylated peptides by NCA polymerization for recognition of human T-cells

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