Multi-functionalization of helical block copoly(α-peptide)s by orthogonal chemistry

文献情報

出版日 2011-03-11

DOI 10.1039/C1PY00015B

インパクトファクター 5.582

著者

Haoyu Tang, Donghui Zhang

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要旨

Diblock copoly(α-peptide)s bearing functional side-chains (i.e., azido or allyl) that are readily derivatized by “click” chemistry have been synthesized by primary amine-initiated sequential polymerization of the corresponding N-carboxyanhydrides (NCAs). Facile derivation of the side-chains has been demonstrated, in which mannose moieties are quantitatively attached via the alkyne–azide [2 + 3] Huisgen cycloaddition to form amphiphilic block copoly(α-peptide)s that retain their helical conformations in solution. Allyl side-chains residing in the hydrophobic core can be further functionalized with high efficiency by radical thiol–ene addition reactions despite the tendency of the amphiphilic precursors to aggregate.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

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Multi-functionalization of helical block copoly(α-peptide)s by orthogonal chemistry

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