Oligoagarose-g-polycaprolactone loaded nanoparticles for drug delivery applications

文献情報

出版日 2010-10-29

DOI 10.1039/C0PY00311E

インパクトファクター 5.582

著者

Archana Bhaw-Luximon, Laila Musharat Meeram, Yeshma Jugdawa, William Helbert, Dhanjay Jhurry

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要旨

Well-defined oligoagarose-g-polycaprolactone copolymers of varying PCL chain lengths have been synthesised using protection/deprotection chemistry. The graft copolymers showed amphiphilic behaviour with spherical micelles in the size range 10 to 20 nm. Ketoprofen was loaded into the core of the micelles. The drug loading efficiency was shown to increase with the length of the hydrophobic PCL chain: 2% for PCL10 and 5.5% for PCL15. Sustained drug release was observed over a period of 72 h and was faster with shorter PCL chains.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Oligoagarose-g-polycaprolactone loaded nanoparticles for drug delivery applications

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