Optimised ‘click’ synthesis of glycopolymers with mono/di- and trisaccharides

文献情報

出版日 2010-10-04

DOI 10.1039/C0PY00260G

インパクトファクター 5.582

著者

Nicola Vinson, Yanzi Gou, C. Remzi Becer, David M. Haddleton, Matthew I. Gibson

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要旨

In this paper we investigate the optimum procedure for the post-polymerisation modification of alkyne-bearing polymer scaffolds with glycosyl azides. We first elaborate the one-pot synthesis of glycosyl azides, in aqueous solution, without the need for protecting groups and in multigram scale. Using these azides, the ligand tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine (TBTA) was shown to give the fastest kinetics for the ‘click’ reaction at ambient temperature, and was used to prepare homogenous oligosaccharide-modified glycopolymers. The terminal sugars of these oligosaccharides were used to introduce α-linked glucose which is typically synthetically challenging.

掲載誌

Polymer Chemistry

CiteScore: 8.6

自己引用率: 7.3%

年間論文数: 457

Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.

Optimised ‘click’ synthesis of glycopolymers with mono/di- and trisaccharides

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