Independent metal-binding features of recombinant metallothioneins convergently draw a step gradation between Zn- and Cu-thioneins
文献情報
Roger Bofill, Mercè Capdevila, Sílvia Atrian
Data on the metal-binding behaviour of circa 20 recombinant metallothioneins (MTs) from evolutionary divergent organisms, gathered after years of systematic research, are here comprehensively analyzed. The consideration of four independent in vivo and in vitro metal-binding features reveals a gradation of the metal-binding character of the MTs considered that significantly coincides in a robust new classification: a stepwise gradation between Zn- and Cu-thioneins. The intermediate positions in this list are occupied by a group of polyvalent MTs, exhibiting a merging Zn-/Cu-thionein character that would suit general metal handling purposes. In contrast, the extreme positions are respectively occupied by those MTs that would have evolved to fulfil specialized Zn- or Cu-related physiological roles. Overall, the analyzed trends allow the proposal of a chemically- and biologically-sound new reflection on MT classification criteria.
おすすめジャーナル

Photochemical & Photobiological Sciences

Journal of Enzyme inhibition and Medicinal Chemistry

Current Pharmaceutical Biotechnology

Foundations of Chemistry

Molecules

Environmental Toxicology and Pharmacology

Coloration Technology

Faraday Discussions

European Journal of Organic Chemistry

Contact Lens & Anterior Eye
関連文献
Exploring the complexity of quantum control optimization trajectories
Arun Nanduri, Ofer M. Shir, Ashley Donovan, Tak-San Ho, Herschel Rabitz
DOI: 10.1039/C4CP03853C
Electronic structures at the interface between Au and CH3NH3PbI3
Xiaoliang Liu, Chenggong Wang, Lu Lyu, Congcong Wang, Zhengguo Xiao, Cheng Bi, Jinsong Huang, Yongli Gao
DOI: 10.1039/C4CP03842H
Molecular charge transfer by adsorbing TCNQ/TTF molecules via π–π interaction: a simple and effective strategy to modulate the electronic and magnetic behaviors of zigzag SiC nanoribbons
Dan Liu, Guangtao Yu, Yuanhui Sun, Xuri Huang, Jia Guan, Hui Zhang, Hui Li, Wei Chen
DOI: 10.1039/C4CP03690E
A novel two-dimensional MgB6 crystal: metal-layer stabilized boron kagome lattice
Sheng-Yi Xie, Xian-Bin Li, Nian-Ke Chen, Yeliang Wang, Shengbai Zhang, Hong-Bo Sun
DOI: 10.1039/C4CP03728F
Surface redox chemistry and mechanochemistry of insulating polystyrene nanospheres
Thomas S. Varley, Martin Rosillo-Lopez, Sandeep Sehmi, Nathan Hollingsworth, Katherine B. Holt
DOI: 10.1039/C4CP03938F
An experimental and theoretical study of the gas phase kinetics of atomic chlorine reactions with CH3NH2, (CH3)2NH, and (CH3)3N
J. M. Nicovich, S. Mazumder, P. L. Laine, Y. Tang, A. J. C. Bunkan, C. J. Nielsen
DOI: 10.1039/C4CP03801K
Intra-residue interactions in proteins: interplay between serine or cysteine side chains and backbone conformations, revealed by laser spectroscopy of isolated model peptides
Himansu S. Biswal
DOI: 10.1039/C4CP04449E
Electronic properties of PbX3CH3NH3 (X = Cl, Br, I) compounds for photovoltaic and photocatalytic applications
Sigismund Teunis Alexander George Melissen, Frédéric Labat, Philippe Sautet, Tangui Le Bahers
DOI: 10.1039/C4CP04666H
Size selected clusters and particles: from physical chemistry and chemical physics to catalysis
DOI: 10.1039/C4CP90163K
Dirac fermions in silicene on Pb(111) surface
Agata Podsiadły-Paszkowska, Mariusz Krawiec
DOI: 10.1039/C4CP05104A
こちらもおすすめ
1-{3-[5-(エチルカルボンイル)-2,4-ジメチル-1H-ピロロール-3-基]プロパニル}ピペリジン-4-カルボン酸について、適用される法規ガイドラインは何ですか?
この化合物はCAS番号1142209-81-1であり、GHS分類では corrosive (腐食性物質) と classified (分類物質) として指定され...
2,2-二氟-1,3-ベンゾジオキサン-5-カルボキシlic酸とは何ですか?
2,2-二氟-1,3-ベンゾジオキサン-5-カルボキシlic酸は、CAS番号656-46-2の化合物で、化学式はC8H4F2O4です。この化合物は白色の結晶性粉...
8-氯-4-色原酮の代替品はありますか?
8-氯-4-色原酮(CAS番号: 49701-11-3)の代替品には、他の色原酮類似物や、構造が似ている化合物があります。例えば、8-メチル-4-色原酮や、他の...
エチル6,6-ジメチル-4,5,6,7-テトラヒドロ-1H-インドアゼー-3-カルボキシレートとは何ですか?
エチル6,6-ジメチル-4,5,6,7-テトラヒドロ-1H-インドアゼー-3-カルボキシレートは、CAS番号1233243-56-5を有する化合物です。これは有...
4-叔丁基-6-氯-嘧啶に適用される法規ガイドラインは何ですか?
4-叔丁基-6-氯-嘧啶はCAS番号3435-24-3で、GHS分類では毒性物質とみなし、GHSの危険性分類が適用されます。REACH規則では登録が必要で、Eu...
維库溴铵杂质Bはどのように合成されますか?
維库溴铵杂质Bは、アンドロステンデンから始まり、一連の合成反応、包括的な選択性と高い収率で合成されます。具体的には、ブロミド化、酸化、ジマーゼ反応、アミド化など...
2-(4-氟苄基)-吡咯烷の物理化学的性質は何ですか?
CAS番号350017-04-8の2-(4-氟苄基)-吡咯烷は、結晶性の白色粉末です。分子量は199.17 g/molで、水に溶けにくいです。化学反応では比較的...
3-喹啉甲醛(2-チロール-8-エチル)は安全ですか?
3-喹啉甲醛(2-チロール-8-エチル)は一定の毒性を持つため、取扱には注意が必要です。使用する際は適切な防護具を着用し、密閉容器で保管・搬送し、直接的な接触を...
エチル3-(ヒドロキシメチル)-1H-ピロール-2-カルボキシレートはどのように保存すればよいですか?
エチル3-(ヒドロキシメチル)-1H-ピロール-2-カルボキシレートは、室温(25℃)以下で保存し、直射日光を避け、乾燥した環境で保管することが推奨されます。ま...
掲載誌
Metallomics

Metallomics publishes cutting-edge investigations aimed at elucidating the identification, distribution, dynamics, role and impact of metals and metalloids in biological systems. Studies that address the “what, where, when, how and why” of these inorganic elements in cells, tissues, organisms, and various environmental niches are welcome, especially those employing multidisciplinary approaches drawn from the analytical, bioinorganic, medicinal, environmental, biophysical, cell biology, plant biology and chemical biology communities. We are particularly interested in articles that enhance our chemical and/or physical understanding of the molecular mechanisms of metal-dependent life processes, and those that probe the common space between metallomics and other ‘omics approaches to uncover new insights into biological processes. Metallomics seeks to position itself at the forefront of those advances in analytical chemistry destined to clarify the enormous complexity of biological systems. As such, we particularly welcome those papers that outline cutting-edge analytical technologies, e.g., in the development and application of powerful new imaging, spectroscopic and mass spectrometric modalities. Work that describes new insights into metal speciation, trafficking and dynamics in complex systems or as a function of microenvironment are also strongly encouraged. Studies that examine the interconnectivity of metal-dependent processes with systems level responses relevant to organismal health or disease are also strongly encouraged, for example those that probe the effect of chemical exposure on metal homeostasis or the impact of metal-based drugs on cellular processes.




