99m-Technetium carbohydrate conjugates as potential agents in molecular imaging

文献情報

出版日 2008-09-12

DOI 10.1039/B809365B

インパクトファクター 6.222

著者

Meryn L. Bowen, Chris Orvig

原文を見る

要旨

This feature article covers recent reports of work towards the development of 99mTc–carbohydrate based agents for use in SPECT imaging, particularly of cancerous tissue. An outline of some of the key biological functions and coordination chemistry of carbohydrates is given, along with an introduction to bioconjugation and molecular imaging. Technetium coordination chemistry and the subset of this involving bioconjugates are discussed before moving into the focus of the article: glycoconjugates of 99mTc(V) and the more recently developed [99mTc(I)(CO)3]+. Significant work in the last decade has featured the very attractive [99mTc(CO)3]+ core, and the ligand sets designed for this core are discussed in detail.

掲載誌

Chemical Communications

CiteScore: 8.6

自己引用率: 4.7%

年間論文数: 2458

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry