Band spreading control in electrophoresis microchips by localized zeta-potential variation using field-effect

文献情報

出版日 2004-08-10

DOI 10.1039/B407627N

インパクトファクター 4.616

著者

Chia-Yen Lee, Che-Hsin Lin, Lung-Ming Fu

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要旨

The paper proposes a new technique, which varies the zeta potential along the channel walls in the vicinity of the microchannel corners in such as a way as to minimize the effects of turn-induced dispersion within U-shaped separation channels. The effects of the separation channel geometry, the fluid velocity profile, and boundary control of the zeta potential on the band distribution in the detection area are all discussed within this paper. The results for the folded square U-shaped separation channel indicate that boundary control of the zeta potential by field-effect significantly reduces the band dispersion induced by the 90° turns. Finally, the results confirm that application of the proposed localized zeta potential variation method results in a correction of the band tilting phenomenon and a reduction in the racetrack effect.

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CiteScore: 7.8

自己引用率: 5.6%

年間論文数: 653

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Band spreading control in electrophoresis microchips by localized zeta-potential variation using field-effect

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