Characterisation of the interactions of aromatic amino acids with diacetyl phosphatidylcholine
文献情報
John M. Sanderson, Eleanor J. Whelan
A simple bimolecular system for characterising the interactions of amino acids with diacyl-3-phosphatidylcholines has been developed. The system contains two components: an N-acetyl amino acid N′-alkyl amide and diacetyl-3-sn-phosphatidylcholine (DAPC). Interactions between a series of aromatic amino acids and DAPC have been characterised by 1H NMR techniques. Of the amino acids examined, tryptophan and tyrosine were shown to have particularly favourable interactions with the DAPC choline headgroup. Our observations are consistent with the previously reported tendency for these amino acids to occur preferentially at the lipid-water interface. Using data from ROESY experiments and complexation-induced chemical shift changes, we have been able to generate molecular models for the tryptophan–DAPC adduct that are consistent with the observed results. The adduct is characterised by amide carbonyl–cation interactions, hydrogen bonding and cation–π interactions.
関連文献
Self-doping of molecular quantum-dot cellular automata: mixed valence zwitterions
Yuhui Lu, Craig Lent
DOI: 10.1039/C1CP21332F
Steady-state photoinduced absorption of CdSe/CdS octapod shaped nanocrystals
Maria Rosa Antognazza, Francesco Scotognella, Karol Miszta, Dirk Dorfs, Marco Zanella, Margherita Zavelani-Rossi, Liberato Manna, Francesco Tassone
DOI: 10.1039/C1CP21402K
Modus operandi of controlled release from mesoporous matrices: a theoretical perspective
Tina Ukmar, Miran Gaberšček, Franci Merzel, Aljaž Godec
DOI: 10.1039/C1CP20636B
Questioning the photophysical model for the indolechromophore in the light of evidence obtained by controlling the non-specific effect of the medium with 1-chlorobutane as solvent
Juan Pablo Catalán
DOI: 10.1039/C1CP21380F
Double layer capacitance of anode/solid-electrolyte interfaces
DOI: 10.1039/C1CP20508K
Intramolecular charge transfer and dual fluorescence of 4-(dimethylamino)benzonitrile: ultrafast branching followed by a two-fold decay mechanism‡
Pedro B. Coto, Luis Serrano-Andrés, Thomas Gustavsson, Takashige Fujiwara, Edward C. Lim
DOI: 10.1039/C1CP21089K
Defect processes in orthorhombic LnBaCo2O5.5 double perovskites
I. D. Seymour, A. Chroneos, J. A. Kilner, R. W. Grimes
DOI: 10.1039/C1CP21471C
Existence of time-dependent density-functional theory for open electronic systems: Time-dependent holographic electron density theorem
Xiao Zheng, ChiYung Yam, Fan Wang, GuanHua Chen
DOI: 10.1039/C1CP20777F
Excitons in semiconducting carbon nanotubes: diameter-dependent photoluminescence spectra
Yoshihiko Kanemitsu
DOI: 10.1039/C1CP21235D
こちらもおすすめ
2-ヒドロキシ-5-ニトロベンジンブロモイドの代替品はありますか?
2-ヒドロキシ-5-ニトロベンジンブロモイドは特定の化学反応に適しているため、代替品は限られています。しかし、同様の構造を持つ2-ヒドロキシ-4-ニトロベンジン...
N-(2-ブロモフェニル)-1-チロール-3-オキソ-3-(ピペリジニル)プロペン-2-イル)ベンゼンアミドを取り扱う際の実験室安全事項は何ですか?
N-(2-ブロモフェニル)-1-チロール-3-オキソ-3-(ピペリジニル)プロペン-2-イル)ベンゼンアミドは有毒で、皮膚や粘膜に刺激を与える可能性があります。...
1,3プロパンジオール,2-[2-(2アミノ-6クロロ-9Hピリミジン-9-イル)エチル-1,1,2,2-D4]-2,3-ジアセタートの市場動向や研究トレンドはどうですか?
この化合物は、新規治療薬の開発に注目されています。市場では、その有効性と安全性が評価され、研究分野では、分子生物学と医薬化学の新たな発見が期待されています。
Succinimidyl-alanyl-phenylalanyl-prolyl-phenylalanine 4-nitroanilide はどの業界で使用されていますか?
Succinimidyl-alanyl-phenylalanyl-prolyl-phenylalanine 4-nitroanilide は主に医薬品開発やポ...
メチル6-アミノ-5-クロロピリジン-2-カーボイル酸について、適用される法規ガイドラインは何ですか?
メチル6-アミノ-5-クロロピリジン-2-カーボイル酸(CAS番号: 1256794-05-4)の使用には、GHS( Globally Harmonized S...
エチル4-(シクロ Pentagonyl)アミノ-2-メチル硫化基ピリミジン-5-カルボキシレートを取り扱う際の実験室安全事項は何ですか?
取り扱いには、耐薬品性の容器を使用し、通気性の良い場所で操作することを推奨します。漏れ時は、SDS(安全データシート)を参照して適切な措置を取ること。手洗いと洗...
(S)-3-ベンZYルピペリジン塩酸塩とは何ですか?
(S)-3-ベンZYルピペリジン塩酸塩は、CAS番号1258940-00-9で表される化合物です。これは、(S)-3-苯基哌啶的盐酸盐であり、主に医薬品の原料と...
3,5-二甲基金剛胺の主な用途は何ですか?
3,5-二甲基金剛胺は、主に医薬品の原料として使用され、また抗うつ薬や抗アルツハイマー薬の開発に利用されます。さらに、化粧品や食品添加物の製造でも重要な役割を果...
ビス(4-メチル-2-ペンチル)フェニルカルボン酸エステルの代替品はありますか?
ビス(4-メチル-2-ペンチル)フェニルカルボン酸エステル (CAS番号: 1398066-13-1) の代替品には、ビス(2-エチルヘキシル)フェノールカルボ...
掲載誌
Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.














![5-Methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-amine structure 5-Methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-amine structure](https://static.chemtradehub.com/structs/122/1227210-33-4-8d64.webp)