Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidases

文献情報

出版日 2003-03-20

DOI 10.1039/B301592K

インパクトファクター 6.222

著者

Annabelle Varrot, James Macdonald, Robert V. Stick, Gavin Pell, Harry J. Gilbert, Gideon J. Davies

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要旨

A cellobio-derived isofagomine glycosidase inhibitor (Ki ∼ 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.

掲載誌

Chemical Communications

CiteScore: 8.6

自己引用率: 4.7%

年間論文数: 2458

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidases

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