化合物よくある質問
EGFR-IN-7はどのように合成されますか？
回答
![5-Bromo-N~4~-[5-(dimethylphosphoryl)-6-quinoxalinyl]-N~2~-{2-methoxy-5-methyl-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}-2,4-pyrimidinediamine](https://static.chemtradehub.com/structs/226/2267329-76-8-d93e.webp "5-Bromo-N~4~-[5-(dimethylphosphoryl)-6-quinoxalinyl]-N~2~-{2-methoxy-5-methyl-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}-2,4-pyrimidinediamine")
EGFR-IN-7は、dimethyl phosphateと6-quinoxaline carboxaldehydeを反応させて生成された5-(dimethylphosphoryl)-6-quinoxaline carboxaldehydeと、2-methoxy-5-methyl-4-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenylamineを有機合成反応で合成します。この反応は、適切な触媒と選択性が得られ、収率は良好です。
について
CAS番号
2267329-76-8
英語名前
5-Bromo-N~4~-[5-(dimethylphosphoryl)-6-quinoxalinyl]-N~2~-{2-methoxy-5-methyl-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}-2,4-pyrimidinediamine
分子式
C32H41BrN9O2P
分子量
694.62 g/mol
SMILES
COC1=C(NC2=NC(Nc3ccc4nccnc4c3P(C)(C)=O)=C(Br)C=N2)C=C(C)C(=C1)N1CCC(CC1)N1CCN(C)CC1
InChIKey
ZYSKXRAGBGLELB-UHFFFAOYSA-N
最後の更新: 2025-12-29 01:16
![5-Bromo-N~4~-[5-(dimethylphosphoryl)-6-quinoxalinyl]-N~2~-{2-methoxy-5-methyl-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}-2,4-pyrimidinediamine — MedChemExpress LLC](https://static.chemtradehub.com/suppliers/67ced0fb2b2de6e8e95a67fd/67ced0fb2b2de6e8e95a67fd-logo.webp){kind=logo}
![5-Bromo-N~4~-[5-(dimethylphosphoryl)-6-quinoxalinyl]-N~2~-{2-methoxy-5-methyl-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}-2,4-pyrimidinediamine — 湖北揚信薬 frosting科技有限公司](https://static.chemtradehub.com/suppliers/67cded3957537e5c8069af88/67cded3957537e5c8069af88-logo.webp){kind=logo}