化合物よくある質問
安西奈德はどのように合成されますか？
回答
![2-[(4a'S,4b'R,5'S,6a'S,6b'S,9a'R,10a'S,10b'S)-4b'-Fluoro-5'-hydroxy-4a',6a'-dimethyl-2'-oxo-2',4a',4b',5',6',6a',9a',10',10a',10b',11',12'-dodecahydro-6b'H-spiro[cyclopentane-1,8'-naphtho[2',1':4,5]in
deno[1,2-d][1,3]dioxol]-6b'-yl]-2-oxoethyl acetate](https://static.chemtradehub.com/structs/510/51022-69-6-c351.webp "2-[(4a'S,4b'R,5'S,6a'S,6b'S,9a'R,10a'S,10b'S)-4b'-Fluoro-5'-hydroxy-4a',6a'-dimethyl-2'-oxo-2',4a',4b',5',6',6a',9a',10',10a',10b',11',12'-dodecahydro-6b'H-spiro[cyclopentane-1,8'-naphtho[2',1':4,5]in
deno[1,2-d][1,3]dioxol]-6b'-yl]-2-oxoethyl acetate")
安西奈德は複雑な構造を持つため、一般的な合成方法は高度な有機合成技術が必要です。主にスピロ構造の前駆体から開始して、フ luoro置換、水酸基導入、メチル基導入などの反応を経て合成されます。触媒の使用や選択性の制御が重要です。
について
CAS番号
51022-69-6
英語名前
2-[(4a'S,4b'R,5'S,6a'S,6b'S,9a'R,10a'S,10b'S)-4b'-Fluoro-5'-hydroxy-4a',6a'-dimethyl-2'-oxo-2',4a',4b',5',6',6a',9a',10',10a',10b',11',12'-dodecahydro-6b'H-spiro[cyclopentane-1,8'-naphtho[2',1':4,5]in
deno[1,2-d][1,3]dioxol]-6b'-yl]-2-oxoethyl acetate
分子式
C28H35FO7
分子量
502.58 g/mol
SMILES
CC(=O)OCC(=O)[C@]12OC3(CCCC3)O[C@@H]2C[C@H]4[C@@H]5CCC6=CC(=O)C=C[C@]6(C)[C@@]5(F)[C@@H](O)C[C@@]41C
InChIKey
ILKJAFIWWBXGDU-MOGDOJJUSA-N
最後の更新: 2025-10-17 13:01
![2-[(4a'S,4b'R,5'S,6a'S,6b'S,9a'R,10a'S,10b'S)-4b'-Fluoro-5'-hydroxy-4a',6a'-dimethyl-2'-oxo-2',4a',4b',5',6',6a',9a',10',10a',10b',11',12'-dodecahydro-6b'H-spiro[cyclopentane-1,8'-naphtho[2',1':4,5]in
deno[1,2-d][1,3]dioxol]-6b'-yl]-2-oxoethyl acetate — 上海绩祥生物科技有限公司](https://static.chemtradehub.com/suppliers/67ce6f4d2b2de6e8e95a45bf/67ce6f4d2b2de6e8e95a45bf-logo.webp){kind=logo}
![2-[(4a'S,4b'R,5'S,6a'S,6b'S,9a'R,10a'S,10b'S)-4b'-Fluoro-5'-hydroxy-4a',6a'-dimethyl-2'-oxo-2',4a',4b',5',6',6a',9a',10',10a',10b',11',12'-dodecahydro-6b'H-spiro[cyclopentane-1,8'-naphtho[2',1':4,5]in
deno[1,2-d][1,3]dioxol]-6b'-yl]-2-oxoethyl acetate — 湖北揚信薬 frosting科技有限公司](https://static.chemtradehub.com/suppliers/67cded3957537e5c8069af88/67cded3957537e5c8069af88-logo.webp){kind=logo}