Hydroxyapatite nanoparticle-modified porous bone grafts with improved cell attachment

文献情報

出版日 2023-10-19

DOI 10.1039/D3TB01839C

インパクトファクター 6.331

著者

Prachi Dhavalikar, Dana Jenkins, Natalie Rosen, Aparajith Kannapiran, Karim Salhadar, Orren Shachaf, Michael Silverstein, Elizabeth Cosgriff-Hernández

原文を見る

要旨

Emulsion-templated foams have displayed promise as injectable bone grafts; however, the use of a surfactant as an emulsifier resulted in relatively small pores and impedes cell attachment. Hydroxyapatite nanoparticles were explored as an alternative stabilizer to address these limitations. To this end, hydroxyapatite nanoparticles were first modified with myristic acid to generate the appropriate balance of hydrophobicity to stabilize a water-in-oil emulsion of neopentyl glycol diacrylate and 1,4-butanedithiol. In situ surface modification of the resulting foam with hydroxyapatite was confirmed with elemental mapping and transmission electron microscopy. Nanoparticle-stabilized foams displayed improved human mesenchymal stem cell viability (91 ± 5%) over surfactant-stabilized foams (23 ± 11%). Although the pore size was appropriate for bone grafting applications (115 ± 71 μm), the foams lacked the interconnected architecture necessary for cell infiltration. We hypothesized that a co-stabilization approach with both surfactant and nanoparticles could be used to achieve interconnected pores while maintaining improved cell attachment and larger pore sizes. A range of hydroxyapatite nanoparticle and surfactant concentrations were investigated to determine the effects on microarchitecture and cell behavior. By balancing these interactions, a co-stabilized foam was identified that possessed large, interconnected pores (108 ± 67 μm) and improved cell viability and attachment. The co-stabilized foam was then evaluated as an injectable bone graft including network formation, microscale integration with bone, push out strength, and compressive properties. Overall, this work demonstrated that in situ surface modification with nHA improved cell attachment while retaining desirable bone grafting features and injectability.

掲載誌

Journal of Materials Chemistry B

CiteScore: 12

自己引用率: 4.9%

年間論文数: 831

Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. The journals have a strong history of publishing quality reports of interest to interdisciplinary communities and providing an efficient and rigorous service through peer review and publication. The journals are led by an international team of Editors-in-Chief and Associate Editors who are all active researchers in their fields. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C. More than one Journal of Materials Chemistry journal may be suitable for certain fields and researchers are encouraged to submit their paper to the journal that they feel best fits for their particular article. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive. Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices image block All articles published in Journal of Materials Chemistry B from 2019 onwards will be indexed in MEDLINE®. Articles that primarily focus on providing insight into the underlying science and performance of biomaterials within a biological environment are more suited to our companion journal, Biomaterials Science.

Hydroxyapatite nanoparticle-modified porous bone grafts with improved cell attachment

文献情報

おすすめジャーナル

関連文献

High-yield graphene produced from the synergistic effect of inflated temperature and gelatin offers high stability and cellular compatibility

Theoretical and experimental investigations of 129Xe NMR chemical shift isotherms in metal–organic frameworks

A DFT analysis of the ground and charge-transfer excited states of Sc3N@Ih–C80 fullerene coupled with metal-free and zinc-phthalocyanine

Multiporous sp2-hybridized boron nitride (d-BN): stability, mechanical properties, lattice thermal conductivity and promising application in energy storage

Contents list

Front cover

Relativistic corrections to the ground states of HD and D2 calculated without using the Born–Oppenheimer approximation

Efficient intersystem crossing in 2-aminopurine riboside probed by femtosecond time-resolved transient vibrational absorption spectroscopy

CO2 interaction with violarite (FeNi2S4) surfaces: a dispersion-corrected DFT study

An insight into the effects of transition metals on the thermal expansion of complex perovskite compounds: an experimental and density functional theory investigation

こちらもおすすめ

2-ブロモ-9,9-ジフェニル-9H-フルオレンの主な用途は何ですか？

四氯化铱の市場動向や研究トレンドはどうですか？

4-硝基肉桂酸はどの業界で使用されていますか？

1-(4-溴-3-氟苯基)-2-氯乙酮を含む廃棄物はどのように処理すべきですか？

苦参酚Kとは何ですか？

POTASSIUM (1-(TERTBUTOXYCARBONYL)AZETIDIN-3-YL)TRIFLUOROBORATE を含む廃棄物はどのように処理すべきですか？

4-庚基-4’-联苯羧酸の市場動向や研究トレンドはどうですか？

6-ブロモ-3-メトキシ-1-フェニル-1H-インドゾールを含む廃棄物はどのように処理すべきですか？

4,4-二甲基-2-吡咯烷酮はどの業界で使用されていますか？

リン酸鉍はどのように保存すればよいですか？

掲載誌

Journal of Materials Chemistry B

おすすめ化合物

3-(3-Ethyl-1-methyl-3-azepanyl)phenol hydrochloride (1:1)

Chloromethyl ethyl carbonate

(1H-Benzotriazol-1-yloxy)(di-1-pyrrolidinyl)methylium hexafluorophosphate

3-bromo-5-(trifluoromethyl)benzoic acid

2-Amino-4-(S-butylsulfonimidoyl)butanoic acid

おすすめサプライヤー