Self-driven immune checkpoint blockade and spatiotemporal-sensitive immune response monitoring in acute myeloid leukemia using an all-in-one turn-on bionanoprobe
文献情報
Honglian Wu, Tianci Wang, Yuting Wang, Sixi Liu, Feiqiu Wen, Gerile Oudeng, Mo Yang
Immune checkpoint (ICP) blockade (ICB) is one of the most promising immunotherapies for acute myeloid leukemia (AML). However, owing to their heterogeneity, AML cells may cause uncoordinated metabolic fluxes and heterogeneous immune responses, inducing the release of a spatiotemporally sensitive immune response marker. Timely and in situ detection of immune responses in ICB therapy is important for therapeutic strategy adjustment. Herein, we constructed an all-in-one nanoprobe for self-driving ICB and simultaneously detecting an immune response in the same AML cell in vivo, thus enabling accurate evaluation of heterogenetic immune responses in living AML mice without additional drug treatment or probe processes. The nature-inspire polydopamine (PDA) nanoparticles loaded with an ICP blocker were targeted to the leukocyte immunoglobulin like receptor B4 (a new ICP) of AML cells to induce the release of immune response marker granzyme B (GrB). The PDA nanoparticles were additionally paired with carbon-derived graphene quantum dots (GQDs) to construct a full-organic ‘turn-on’ bionanoprobe that can transfer fluorescence resonance energy for GrB detection. This multifunctional nanoprobe was validated for triggering ICB therapy and monitoring the changes of GrB levels in real-time both in vitro and in vivo. The organic nanoprobe showed excellent permeability and retention in tumor cells and high biocompatibility in vivo. This bionanoprobe orderly interacted with the upstream ICP molecules and downstream signal molecule GrB, thereby achieving in situ immune response signals within the therapeutic efficacy evaluation window.
おすすめジャーナル

Bioorganic & Medicinal Chemistry

Biocatalysis and Biotransformation

Acta Metallurgica Sinica-English Letters

Heteroatom Chemistry

Topics in Catalysis

Critical Reviews in Solid State and Materials Sciences

Journal of Asian Natural Products Research

Journal of Chemical Sciences

Polycyclic Aromatic Compounds

Chinese Journal of Chemistry
関連文献
New data on photochemistry of the interstellar molecule: HNCS. Identification of the S⋯HCN complex
Justyna Krupa, Iwona Kosendiak, Maria Wierzejewska
DOI: 10.1039/C5CP03663A
A means to an interface: investigating monoethanolamine behavior at an aqueous surface
Laura E. McWilliams, Nicholas A. Valley, Sumi N. Wren, Geraldine L. Richmond
DOI: 10.1039/C5CP02931G
Surface enhanced vibrational spectroscopy and first-principles study of l-cysteine adsorption on noble trimetallic Au/Pt@Rh clusters
B. Loganathan, V. L. Chandraboss, S. Senthilvelan, B. Karthikeyan
DOI: 10.1039/C4CP05170J
Direct formation of large-scale multi-layered germanene on Si substrate
Hsu-Sheng Tsai, Yu-Ze Chen, Henry Medina, Teng-Yu Su, Ta-Shun Chou, Yi-Hsuan Chen, Yu-Lun Chueh, Jenq-Horng Liang
DOI: 10.1039/C5CP02469B
A cocatalyst-free Eosin Y-sensitized p-type of Co3O4 quantum dot for highly efficient and stable visible-light-driven water reduction and hydrogen production
Ning Zhang, Jinwen Shi, Fujun Niu, Jian Wang, Liejin Guo
DOI: 10.1039/C5CP02983J
Mesoscopic modeling of structural and thermodynamic properties of fluids confined by rough surfaces
Ketzasmin A. Terrón-Mejía, Roberto López-Rendón, Armando Gama Goicochea
DOI: 10.1039/C5CP03823E
Tip-enhanced Raman spectroscopy of graphene-like and graphitic platelets on ultraflat gold nanoplates
Farshid Pashaee, Faranak Sharifi, Giovanni Fanchini, François Lagugné-Labarthet
DOI: 10.1039/C4CP05252H
High performance surface-enhanced Raman scattering from molecular imprinting polymer capsulated silver spheres
Yan Guo, Leilei Kang, Shaona Chen
DOI: 10.1039/C5CP00206K
On the formation of cyclopentadiene in the C3H5˙ + C2H2 reaction
Jordy Bouwman, Andras Bodi, Patrick Hemberger
DOI: 10.1039/C5CP02243F
Far- and near-field properties of gold nanoshells studied by photoacoustic and surface-enhanced Raman spectroscopies
V. Weber, A. Feis, C. Gellini, R. Pilot, P. R. Salvi, R. Signorini
DOI: 10.1039/C4CP05054A
こちらもおすすめ
3-(2-オキサプロピル)ベンzoic酸はどのように合成されますか?
3-(2-オキサプロピル)ベンzoic酸は、ベンzoic酸とプロパノ酸をヒドロキシム化合物として反応させて生成します。具体的には、ベンzoic酸とプロパノ酸を反...
4-メチル-4-ピペリジニル-1-ピロリドイン甲酸の主な用途は何ですか?
4-メチル-4-ピペリジニル-1-ピロリドイン甲酸は、主に医薬品の合成材料や研究用物質として使用されます。さらに、一部の薬理学的研究にも応用されています。
Biotin-PEG3-oxyamine HCl塩について、適切な化合物名称に適用される法規ガイドラインは何ですか?
Biotin-PEG3-oxyamine HCl塩は、GHS( Globally Harmonized System of Classification and...
N-(4-イソチオシアネートフェニル)-2-メトキシアリニンはどのように合成されますか?
N-(4-イソチオシアネートフェニル)-2-メトキシアリニンは、4-イソチオシアノフェノールと2-メトキシアリニルアミンのアミニド反応を用いて合成されます。この...
金粉蕨亭2'-O-葡萄糖甙の主な用途は何ですか?
金粉蕨亭2'-O-葡萄糖甙は主に薬理研究や医薬品製造に使用され、抗炎症作用や抗がん作用などがあります。また、その構造や性質から、合成化学や化学生理学の研究にも用...
2-(2-ニトロフェニル)酢酸ヒドライドの物理化学的性質は何ですか?
2-(2-ニトロフェニル)酢酸ヒドライドのCAS番号は114953-81-0です。この化合物は白色結晶性粉末で、分子量は244.12です。水溶性は限られており、...
5-(ヒドロキシメチル)-2-チオキソ-2,3-ジヒドロピリミジン-4(1H)-オンを取り扱う際の実験室安全事項は何ですか?
この化合物は高活性のため、取り扱いには注意が必要です。PPE(個人保護具)としてゴーグル、ガントリー、および防滴シールドを着用することが推奨されます。ドラフトチ...
11-脱氢血栓烷 b2の市場動向や研究トレンドはどうですか?
11-脱氢血栓烷 b2は、血栓溶解・抗凝固作用に関する研究で注目を集めています。特に心血管疾患の治療法開発において、市場の需要が高まっています。研究トレンドとし...
3,3-二甲基哌啶-4-酮はどのように保存すればよいですか?
3,3-二甲基哌啶-4-酮は避光、常温、乾燥した場所で保存してください。容器は密閉し、遠くから火源を離して保管することを確認してください。
掲載誌
Journal of Materials Chemistry B

Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. The journals have a strong history of publishing quality reports of interest to interdisciplinary communities and providing an efficient and rigorous service through peer review and publication. The journals are led by an international team of Editors-in-Chief and Associate Editors who are all active researchers in their fields. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C. More than one Journal of Materials Chemistry journal may be suitable for certain fields and researchers are encouraged to submit their paper to the journal that they feel best fits for their particular article. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive. Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices image block All articles published in Journal of Materials Chemistry B from 2019 onwards will be indexed in MEDLINE®. Articles that primarily focus on providing insight into the underlying science and performance of biomaterials within a biological environment are more suited to our companion journal, Biomaterials Science.

![(1R,6R)-6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-3-cyclohexene-1-carboxylic acid structure (1R,6R)-6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-3-cyclohexene-1-carboxylic acid structure](https://static.chemtradehub.com/structs/865/865689-24-3-5fef.webp)
![5-Bromo-3-isopropyl-1H-pyrrolo[2,3-b]pyridine structure 5-Bromo-3-isopropyl-1H-pyrrolo[2,3-b]pyridine structure](https://static.chemtradehub.com/structs/125/1256819-54-1-8620.webp)

![trans-2-{[(Tert-butoxy)carbonyl]amino}cyclobutane-1-carboxylic acid structure trans-2-{[(Tert-butoxy)carbonyl]amino}cyclobutane-1-carboxylic acid structure](https://static.chemtradehub.com/structs/951/951173-25-4-27cd.webp)