Improving the potential of paraCEST through magnetic-coupling induced line sharpening

文献情報

出版日 2023-11-21

DOI 10.1039/D3SC04770A

インパクトファクター 9.825

著者

Xin Guo, Jiesheng Hu, Meng Yu, Gyula Tircsó, Jun Tao

原文を見る

要旨

Magnetic coupling between paramagnetic centers is a crucial phenomenon in the design of efficient MRI contrast agents. In this study, we investigate the paraCEST properties and magnetic coupling effects of a novel homodinuclear Ni(II) complex, 1, containing a Robson type macrocyclic ligand. A thorough analysis of the complex's electronic and magnetic properties revealed that the magnetic coupling effect reduces the transverse relaxation rate and enhances the sharpness of the proton resonances, leading to enhanced CEST efficiency. This novel mechanism, which we coined “magnetic-coupling induced line sharpening” (MILS), can be crucial for optimizing the performance of paramagnetic metal complexes in paraCEST imaging. Moreover, magnetic coupling plays a critical role in the relaxation properties of homodinuclear complexes. Our study not only paves the way for the creation of advanced paraCEST agents with enhanced CEST capabilities and sensitivity but also provides valuable guidance for the design of other MRI contrast agents utilizing dinuclear metal complexes.

掲載誌

Chemical Science

CiteScore: 14.4

自己引用率: 3.9%

年間論文数: 1413

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