Pulsed electrolysis: enhancing primary benzylic C(sp3)–H nucleophilic fluorination

文献情報

出版日 2023-12-13

DOI 10.1039/D3QO01865B

インパクトファクター 5.281

著者

Alexander P. Atkins, Atul K. Chaturvedi, Joseph A. Tate, Alastair J. J. Lennox

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要旨

Electrosynthesis is an efficient and powerful tool for the generation of elusive reactive intermediates. The application of alternative electrolysis waveforms provides a new level of control for dynamic redox environments. Herein, we demonstrate that pulsed electrolysis provides a favourable environment for the generation and fluorination of highly unstable primary benzylic cations from C(sp3)–H bonds. By introduction of a toff period, we propose this waveform modulates the electrical double layer to improve mass transport and limit over-oxidation.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Pulsed electrolysis: enhancing primary benzylic C(sp3)–H nucleophilic fluorination

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