Access to phosphorus-containing cyclopenta[b]benzofuranols via a serendipitous cascade reaction promoted by a bifunctional phosphonium salt

文献情報

出版日 2023-08-07

DOI 10.1039/D3QO00979C

インパクトファクター 5.281

著者

Hui-Lin Hu, Siqiang Fang, Yulin Chen, Wei Wan, Yuqiao Zhou, Zhipeng Xu, Tianli Wang

原文を見る

要旨

In the current work, we serendipitously discovered a cascade reaction of readily available flavonoid derivatives with phosphine oxides by harnessing a bifunctional phosphonium salt catalyst, affording a variety of architecturally complex cyclopenta[b]benzofuranols with phosphorus-containing units in good yields. Mechanistic investigations revealed that this cascade process involved a cumulative diene as the key intermediate. Furthermore, an initial study of an asymmetric version of this reaction was conducted, in which the chiral product was generated in moderate yield with moderate enantioselectivity.

掲載誌

Organic Chemistry Frontiers

CiteScore: 7.8

自己引用率: 8.7%

年間論文数: 724

Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

Access to phosphorus-containing cyclopenta[b]benzofuranols via a serendipitous cascade reaction promoted by a bifunctional phosphonium salt

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