Nitrile stabilized synthesis of pyrrolidine and piperidine derivatives via tandem alkynyl aza-Prins–Ritter reactions

文献情報

出版日 2023-12-14

DOI 10.1039/D3OB01764H

インパクトファクター 3.876

著者

Sudip Shit, Chinmayee Choudhury, Anil K. Saikia

原文を見る

要旨

An efficient methodology for the synthesis of N-(pyrrolidine-3-ylidenemethyl)acetamides mediated by triflic acid in good yields with separable Z/E isomers within a short reaction time has been demonstrated. The reaction involves the initial formation of the pyrrolidin-3-ylidenemethylium carbocation via the Prins cyclization reaction followed by the Ritter reaction to produce N-(pyrrolidine-3-ylidenemethyl)acetamides. This methodology is also used for the synthesis of their piperidine derivatives.

掲載誌

Organic & Biomolecular Chemistry

CiteScore: 3.4

自己引用率: 10.3%

年間論文数: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

Nitrile stabilized synthesis of pyrrolidine and piperidine derivatives via tandem alkynyl aza-Prins–Ritter reactions

文献情報

おすすめジャーナル

関連文献

Using high-throughput virtual screening to explore the optoelectronic property space of organic dyes; finding diketopyrrolopyrrole dyes for dye-sensitized water splitting and solar cells

An anthraquinone-decorated graphene hydrogel based on carbonized cotton fibers for flexible and high performance supercapacitors

Enhanced OER performance of composite Co–Fe-based MOF catalysts via a one-pot ultrasonic-assisted synthetic approach

Tuning the open circuit voltage by incorporating a diflurophenyl unit into a polymer backbone to achieve high efficiency polymer solar cells

The highly selective synthesis of 5-methyl vanillin from the by-product in vanilla industry and the scent influence for vanillin

A comparison of sizing methods for a long-term renewable hybrid system. Case study: Galapagos Islands 2031

An efficient hybrid supercapacitor based on Zn–Mn–Ni–S@NiSe core–shell architectures

Simulation of bi-layer cathode materials with experimentally validated parameters to improve ion diffusion and discharge capacity

Correction: High performance binder-free Fe–Ni hydroxides on nickel foam prepared in piranha solution for the oxygen evolution reaction

Phase-controllable polymerized ionic liquids for CO2 fixation into cyclic carbonates

こちらもおすすめ

5-苄基四氢吡咯并[3,4-c]吡咯-1,3[2H,3ah]-二酮の主な用途は何ですか？

唾液酸路易ス Aを取り扱う際の実験室安全事項は何ですか？

タルトブチル ((1-(2-クロロアセチル)ピペリジン-4-イルメチル)カーバamatはどの業界で使用されていますか？

3-烯丙基-2-羟基苯甲醛の物理化学的性質は何ですか？

乳清酸 Potassium Orotateとは何ですか？

4-甲基苯磺酸异丙酯はどの業界で使用されていますか？

6-(3- Florobenzen)-N-[1-(2,2,2- Trifluoroethyl)-4-Piperidinyl]-3-Pyridinycarboxamideはどの業界で使用されていますか？

左西孟旦はどのように合成されますか？

3-乙氧基哌啶盐酸盐に適用される法規ガイドラインは何ですか？

Diethyl (hydroxymethyl)phosphonateの主な用途は何ですか？

掲載誌

Organic & Biomolecular Chemistry

おすすめ化合物

Ethyl (2,4,5-trifluorophenyl)acetate

2-(4-(Trifluoromethoxy)phenyl)-1H-imidazole

(3S)-Tetrahydro-2H-pyran-3-amine

Dicyclopropylmethanol

Ethyl 5,6-difluoro-1H-indole-2-carboxylate

おすすめサプライヤー