One-pot, efficient synthesis of fused quinoline analogues via room temperature C(sp3)–N cleavage/aromatization reaction

文献情報

出版日 2024-01-02

DOI 10.1039/D3NJ05462D

インパクトファクター 3.591

著者

Subramaniyan Prasanna Kumari, Subbiah Thamotharan, Subramaniapillai Selva Ganesan

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要旨

One-pot transformation of N,N-dimethylaniline to fused quinoline derivatives was achieved through sequential oxidative cyclization followed by a concomitant C(sp3)–N cleavage/aromatization reaction. The transformation was successfully carried out under an air atmosphere at room temperature itself. Mechanistic investigations revealed that the reaction follows the radical pathway. In silico studies showed that the synthesized molecules exhibit good caspase-3 inhibitory activity.

掲載誌

New Journal of Chemistry

CiteScore: 5.3

自己引用率: 3.7%

年間論文数: 2153

NJC (New Journal of Chemistry) is a broad-based primary journal encompassing all branches of chemistry and its sub-disciplines. It contains full research articles, communications, perspectives and focus articles. This well-established journal, owned by the Centre National de la Recherche Scientifique (CNRS) of France, has been co-published with the Royal Society of Chemistry since January 1998. NJC is the forum for the publication of high-quality, original and significant work that opens new directions in chemistry or other scientific disciplines. In addition to having a significant chemical component, work published in NJC must demonstrate that it will have an impact on areas of research other than that of the reported work.

One-pot, efficient synthesis of fused quinoline analogues via room temperature C(sp3)–N cleavage/aromatization reaction

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New Journal of Chemistry

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