PyBroP-mediated nucleophilic addition of oxindoles with pyridine N-oxides to access 3-pyridyl-3,3-disubstituted oxindoles

文献情報

出版日 2023-12-07

DOI 10.1039/D3NJ04907H

インパクトファクター 3.591

著者

Wenjia Xiao, Xiangping Hu

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要旨

A sustainable and efficient strategy for the synthesis of 3-pyridyl-3,3-disubstituted oxindole derivatives has been achieved via PyBroP (bromotripyrrolidinophosphonium hexafluorophosphate) promoted nucleophilic addition reaction of oxindoles with pyridine N-oxides. The approach worked well under relatively mild conditions. The protocol features a broad substrate scope and good functional group tolerance and gives products in moderate to excellent (52–95%) yields.

掲載誌

New Journal of Chemistry

CiteScore: 5.3

自己引用率: 3.7%

年間論文数: 2153

NJC (New Journal of Chemistry) is a broad-based primary journal encompassing all branches of chemistry and its sub-disciplines. It contains full research articles, communications, perspectives and focus articles. This well-established journal, owned by the Centre National de la Recherche Scientifique (CNRS) of France, has been co-published with the Royal Society of Chemistry since January 1998. NJC is the forum for the publication of high-quality, original and significant work that opens new directions in chemistry or other scientific disciplines. In addition to having a significant chemical component, work published in NJC must demonstrate that it will have an impact on areas of research other than that of the reported work.

PyBroP-mediated nucleophilic addition of oxindoles with pyridine N-oxides to access 3-pyridyl-3,3-disubstituted oxindoles

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New Journal of Chemistry

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