Non-target analysis and characterisation of nanoparticles in spirits via single particle ICP-TOF-MS

文献情報

出版日 2023-10-31

DOI 10.1039/D3JA00253E

インパクトファクター 4.023

著者

Raquel Gonzalez de Vega, Thomas E. Lockwood, Lhiam Paton, Lukas Schlatt, David Clases

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要旨

Nanoparticles (NPs) can be found throughout our direct environment as well as in a large range of consumer products. However, there is a lack of data on abundances and properties, which requires dedicated methods to identify and characterise NP entities. Single particle inductively coupled plasma-mass spectrometry (SP ICP-MS) is becoming one of the most relevant methods for counting NPs and studying NP composition and properties. Especially time-of-flight (TOF) technology for ICP-MS holds the key to study single particle composition and to perform non-target particle screening. This is achieved through the unique detection paradigm in TOF acquiring all isotopes across the periodic table at 35 kHz and faster. Nevertheless, non-targeted screening methods face limitations due to two factors. First, large data sets challenge data processing units and require substantial time, and second, for each isotope/element, a decision limit to distinguish between random noise and a SP signal has to be established. Here, we propose a novel lognormal approximation method to rapidly model background levels and decision limits. This method was integrated in a pre-analysis tool which detected SP data signatures of all m/z recorded via SP ICP-TOF-MS. Within seconds, particulate elements could be pinpointed in large data files and selected for more dedicated characterisation steps. In a proof of concept, we used this non-target screening method to identify inorganic NPs in selected samples of whisky, vodka, gin, and liqueur. Following qualitative analyses, number concentrations, compositions, masses, and size distributions were investigated. Besides Mn, Fe and Cu as expected NP entities, Ti, Ag, Au and Sn-based particles were found in investigated samples.

掲載誌

Journal of Analytical Atomic Spectrometry

CiteScore: 6.2

自己引用率: 25.8%

年間論文数: 254

The Journal of Analytical Atomic Spectrometry (JAAS) is the central journal for publishing innovative research on fundamentals, instrumentation, and methods in the determination, speciation and isotopic analysis of (trace) elements within all fields of application. This includes, but is not restricted to, the most recent progress, developments and achievements in all forms of atomic and elemental detection, isotope ratio determination, molecular analysis, plasma-based analysis and X-ray techniques. The journal welcomes full papers, communications, technical notes, critical and tutorial review articles, editorials, and comments, in addition to the Atomic Spectrometry Updates (ASU) literature reviews that are prepared by an expert panel. Submissions are welcome in the following areas, but note this list reflects the current scope and authors are strongly encouraged to contact the Editorial team if they believe that their work offers potentially new and emerging research relevant to the journal remit: Fundamental studies in the following. New and existing sources for atomic emission, absorption, fluorescence and mass spectrometry and those that provide both atomic and molecular information Sample introduction techniques for solids, liquids, gases Improvements in sensitivity, selectivity, precision, accuracy and/or robustness Isotope ratio measurements, including techniques for improving precision and mass bias correction Single channel and multichannel simultaneous detection systems Chemometrics, statistics, calibration techniques and internal standardisation Theoretical and numerical modelling of fundamental processes related to all of the above methodologies Novel or improved methodologies in areas of application including, but not limited to the following. Biosciences, including elemental, speciation and isotopic analysis in biological systems, immunoassays based on metal-labeled antibodies, bio-imaging, and nanoparticle toxicology Geochemistry Environmental science Materials science, including engineered nanoparticles and quantum dots Metrology, including reference materials Forensic analysis Food and agricultural sciences Energy Archaeometry Molecular analysis. Molecular sources for elemental and isotopic analysis Atomic sources for molecular analysis Atomic and molecular techniques simultaneously used for complementary chemical information All contributions are judged on originality and quality of scientific content, and appropriateness of length to content of new science.