Progress in the regulation of pathological crystallization
文献情報
Zhonghua Li, Yingshuang Meng, Mingyang Yu, Xiaobin Jiang, Gaohong He
When the biological environment deviates from a narrow range of internal balance, some substances are crystallized in body fluids and adhere to the surface of human tissues. It causes inflammation, urinary calculi, blockage of the vessel, and other issues. Also, the encrustation of medical devices makes it complicated to treat the diseases. Thus, it is urgent to improve the understanding of the crystallization thermodynamics and interfacial engineering, which has obvious interdisciplinary characteristics in the fields of chemical engineering, materials science, and medicine. This review summarizes the progress in pathological crystallization related to stone diseases. The mechanisms of pathological mineralization are elucidated through overviewing the efforts in crystallization inhibition. Small molecules, macromolecules, nanoparticles, and polymer surfaces capable of inhibiting pathological mineralization are highlighted. Strategies for designing effective inhibitors and modifying the surface of medical polymers are discussed. The main issues in the research of crystallization inhibitors are summarized, and the prospects for future research on pathological crystallization are put forward.
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CrystEngComm

CrystEngComm is the forum for the design and understanding of crystalline materials. We welcome studies on the investigation of molecular behaviour within crystals, control of nucleation and crystal growth, engineering of crystal structures, and construction of crystalline materials with tuneable properties and functions. We publish hypothesis-driven research into… how crystal design affects thermodynamics, phase transitional behaviours, polymorphism, morphology control, solid state reactivity (crystal-crystal solution-crystal, and gas-crystal reactions), optoelectronics, ferroelectric materials, non-linear optics, molecular and bulk magnetism, conductivity and quantum computing, catalysis, absorption and desorption, and mechanical properties. Using Techniques and methods including… Single crystal and powder X-ray, electron, and neutron diffraction, solid-state spectroscopy, spectrometry, and microscopy, modelling and data mining, and empirical, semi-empirical and ab-initio theoretical evaluations. On crystalline and solid-state materials. We particularly welcome work on MOFs, coordination polymers, nanocrystals, host-guest and multi-component molecular materials. We also accept work on peptides and liquid crystals. All papers should involve the use or development of a design or optimisation strategy. Routine structural reports or crystal morphology descriptions, even when combined with an analysis of properties or potential applications, are generally considered to be outside the scope of the journal and are unlikely to be accepted.










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