Intramolecular Ni-catalyzed reductive coupling enables enantiodivergent synthesis of linoxepin

文献情報

出版日 2023-12-11

DOI 10.1039/D3CC05312A

インパクトファクター 6.222

著者

Zi-Hao Liu, Jian Xiao, Qian-Qian Zhai, Xi Tang, Li-Jun Xu, Zhi-Yuan Zhuang, Ya-Wen Wang, Yu Peng

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要旨

A nickel-catalyzed reductive tandem cyclization of the elaborated β-bromo acetal with a dibenzoxepin scaffold was invented to strategically construct the remaining two rings in linoxepin. The generated diasterodivergent intermediates could be easily converted to both enantiomers of this unique cyclolignan molecule via facile oxidations, thus realizing enantiodivergent total synthesis of linoxepin for the first time.

掲載誌

Chemical Communications

CiteScore: 8.6

自己引用率: 4.7%

年間論文数: 2458

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

Intramolecular Ni-catalyzed reductive coupling enables enantiodivergent synthesis of linoxepin

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