Concurrent Cu(ii)-initiated Fenton-like reaction and glutathione depletion to escalate chemodynamic therapy
文献情報
Ashwini Kumar, Ayushi Chaudhary, Bhumika Agrahari, Kajal Chaudhary, Pooran Kumar, Ritika Gautam Singh
Chemodynamic therapy is an evolving therapeutic strategy but there are certain limitations associated with its treatment. Herein, we present de novo synthesis and mechanistic evaluation of HL1–HL8 ligands and their corresponding CuII(L1)2–CuII(L8)2. The most active Cu(L2)2 (IC50 = 5.3 μM, MCF-7) complex exclusively depletes glutathione while simultaneously promoting ROS production. Cu(L2)2 also affects other macromolecules like the mitochondrial membrane and DNA while activating the unfolded protein response cascade.
おすすめジャーナル

Russian Journal of Organic Chemistry

Russian Journal of Applied Chemistry

Russian Chemical Bulletin

Current Opinion in Colloid & Interface Science

Saudi Pharmaceutical Journal

Russian Journal of General Chemistry

Organic Process Research & Development

New Journal of Chemistry

Russian Journal of Bioorganic Chemistry

Crystallography Reports
関連文献
Molecular dynamics study on ions and water confined in the nanometer channel of Friedel's salt: structure, dynamics and interfacial interaction
Penggang Wang, Yuting Jia, Tao Li, Dongshuai Hou, Qi Zheng
DOI: 10.1039/C8CP02450B
Density functional theory (DFT) calculations of VI/V reduction potentials of uranyl coordination complexes in non-aqueous solutions
Krishnamoorthy Arumugam, Neil A. Burton
DOI: 10.1039/C8CP05412F
Shock wave propagation, plasticity, and void collapse in open-cell nanoporous Ta
J. F. Tang, J. C. Xiao, L. Deng, W. Li, X. M. Zhang, L. Wang, S. F. Xiao, H. Q. Deng, W. Y. Hu
DOI: 10.1039/C8CP05126G
Crack propagation in graphene monolayer under tear loading
Yang Cai, Xiaoyi Liu, Xiaohu Yao
DOI: 10.1039/C8CP07477A
Nanoporous gold functionalized with praseodymia–titania mixed oxides as a stable catalyst for the water–gas shift reaction
Christoph Mahr
DOI: 10.1039/C8CP06040A
Determination of band edges and their influences on photocatalytic reduction of nitrobenzene by bulk and exfoliated g-C3N4
Swapna Challagulla, Soumitra Payra, Chanchal Chakraborty, Sounak Roy
DOI: 10.1039/C8CP06855K
Carbon-nitride 2D nanostructures: thermal conductivity and interfacial thermal conductance with the silica substrate
Ali Rajabpour, Saeed Bazrafshan
DOI: 10.1039/C8CP06992A
Plasmon-coupled charge transfer in WO3−x semiconductor nanoarrays: toward highly uniform silver-comparable SERS platforms
Xiangyu Hou, Xiaoguang Luo, Xingce Fan, Zhaohui Peng, Teng Qiu
DOI: 10.1039/C8CP07305H
The role of potassium in the activation of oxygen to promote nitric oxide oxidation on honeycomb-like h-BN(001) surfaces
Fang Wang, Shiqian Wei, Weichuang Yang
DOI: 10.1039/C8CP05527K
Atomistic determination of the surface structure of Cu2O(111): experiment and theory
Rui Zhang, Liang Li, Kelvin B. Chang, Maria K. Y. Chan, Jeffrey R. Guest
DOI: 10.1039/C8CP06023A
こちらもおすすめ
間溴苯甲酰腈の市場動向や研究トレンドはどうですか?
間 brom 苯甲酰腈は、合成化学や薬物化学において重要な Intermediate として使用されています。市場動向としては、その合成性と機能性により、研究開...
Methyl 2-amino-5-(trifluoromethyl)benzoateに適用される法規ガイドラインは何ですか?
CAS番号117324-58-0の塩酸メチル2アミノ-5-トリフルオロメチルベンゼートは、GHS分類により腐食性物質と判定されます。REACH規則では、製造、販...
3-ブロモ-1,3,4,5-四水化-2H-1-ベンザアゼピン-2-オンは安全ですか?
毒性があるため、適切な安全対策が必須です。皮膚や粘膜への刺激性が強く、吸入や誤飲により健康被害を引き起こす可能性があります。取扱時にはガスマスクや手袋、眼鏡を使...
三氟甲基ピリジン-2-甲アミン塩酸塩は安全ですか?
三氟甲基ピリジン-2-甲アミン塩酸塩は安全性に注意が必要です。毒性は低レベルですが、直接的接触や吸入は避けるべきです。適切な手袋や防塵マスクを着用し、密閉された...
1-エチル-4-(4-硝基フェニル)ピペリジンは安全ですか?
1-エチル-4-(4-硝基フェニル)ピペリジンは有毒であり、取扱には注意が必要です。保管や作業中に手袋を着用し、目や皮膚に接触しないように注意する必要があります...
1,1-ジメトキシプロパン-2-オンは安全ですか?
1,1-ジメトキシプロパン-2-オンは一般的に低毒性ですが、皮膚や目への刺激性があるため、取扱いには注意が必要です。蒸気や液体の吸入には有害な可能性があり、適切...
コバルト(II) 3,3'-{[(1S,2S)-1,2-ジメチルフENCYCLICALE-1,2-エチエンジイル]ビス[ニトロリルメチルイリデン]}ビス[4-オキソ-2-ペンテン-2-olate]について「に適用される法規ガイドラインは何ですか?
この化合物はCAS番号259259-80-8に対応しています。GHS分類では、毒性、燃焼性、反応性、炎症性を考慮に入れ、適切な危険性分類が行われます。REACH...
「カーバミル酸, N-[8-[[2-[[2-(2,6-ジオキソ-3-ピペリジニル)-2,3-ジオキソ-1,3-ジヒドロ-1H-イソイソインドール-4-イルオキシ]アセチル]アミノ]オクチル]-1,1-ジメチレチルエステル」はどのように保存すればよいですか?
この化合物は、冷却庫で-20℃の温度、乾燥した容器に保管し、直日光から保護する必要があります。湿度の高い環境や高温は避けてください。
掲載誌
Chemical Communications

ChemComm publishes urgent research which is of outstanding significance and interest to experts in the field, while also appealing to the journal’s broad chemistry readership. Our communication format is ideally suited to short, urgent studies that are of such importance that they require accelerated publication. Our scope covers all topics in chemistry, and research at the interface of chemistry and other disciplines (such as materials science, nanoscience, physics, engineering and biology) where there is a significant novelty in the chemistry aspects. Major topic areas covered include: Analytical Chemistry Catalysis Chemical Biology and medicinal chemistry Computational Chemistry and Machine Learning Energy and sustainable chemistry Environmental Chemistry Green Chemistry Inorganic Chemistry Materials Chemistry Nanoscience Organic Chemistry Physical Chemistry Polymer Chemistry Supramolecular Chemistry

![1,1'-[(E)-1,2-Ethenediyl]bis(4-bromobenzene) structure 1,1'-[(E)-1,2-Ethenediyl]bis(4-bromobenzene) structure](https://static.chemtradehub.com/structs/188/18869-30-2-c907.webp)

![(3R)-3-(3-Fluorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid structure (3R)-3-(3-Fluorophenyl)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid structure](https://static.chemtradehub.com/structs/500/500789-04-8-20dd.webp)
