Palladium-catalyzed difluoroalkylative carbonylation of styrenes toward difluoropentanedioates

文献情報

出版日 2022-08-03

DOI 10.1039/D2SC02665A

インパクトファクター 9.825

著者

Youcan Zhang

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要旨

The introduction of fluorine atoms into organic molecules is an attractive but challenging topic. In this work, an interesting palladium-catalyzed difluoroalkylative carbonylation of aryl olefins has been developed. A wide range of aryl olefins were transformed into the corresponding difluoropentanedioate compounds with good functional-group tolerance and excellent regioselectivity. Inexpensive ethyl bromodifluoroacetate acts both as a difluoroalkyl precursor and a nucleophile here. Additionally, a scale–up reaction was also performed successfully, and further transformations of the obtained product were shown as well.

掲載誌

Chemical Science

CiteScore: 14.4

自己引用率: 3.9%

年間論文数: 1413

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Palladium-catalyzed difluoroalkylative carbonylation of styrenes toward difluoropentanedioates

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